Аморолфин
- английское имяAmorolfine
- CAS №78613-35-1
- CBNumberCB4137272
- ФормулаC21H35NO
- мольный вес317.51
- номер MDLMFCD00865597
- файл Mol78613-35-1.mol
химическое свойство
| Температура кипения | bp0.1 120° |
| плотность | 0.924±0.06 g/cm3(Predicted) |
| растворимость | Chloroform (Slightly), Methanol (Slightly) |
| форма | Oil |
| пка | 7.33±0.10(Predicted) |
| цвет | Colourless |
| InChI | InChI=1/C21H35NO/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22/h8-11,16-18H,7,12-15H2,1-6H3/t16?,17-,18+ |
| ИнЧИКей | MQHLMHIZUIDKOO-AYHJJNSGNA-N |
| SMILES | N1(CC(C)CC2=CC=C(C(C)(C)CC)C=C2)C[C@H](C)O[C@H](C)C1 |&1:17,20,r| |
| Справочник по базе данных CAS | 78613-35-1(CAS DataBase Reference) |
| FDA UNII | AB0BHP2FH0 |
| Коды опасности | Xn |
| Заявления о рисках | 20/21/22-36/37/38 |
| Заявления о безопасности | 26-36 |
Аморолфин химические свойства, назначение, производство
Определение
ChEBI: A member of the class of morpholines that is cis-2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a racemic 2-methyl-3-[p-(2-methylbutan-2-yl)phenyl]propyl group. An inhibitor of the action f squalene monooxygenase, Delta14 reductase and D7-D8 isomerase and an antifungal agent, it is used (generally as its hydrochloride salt) for the topical treatment of fungal nail and skin infections.Антимикробная активность
Amorolfine is a broad-spectrum antimycotic with in vitro activity against dermatophytes, pathogenicCandida species, and a variety of pathogenic dimophic fungi such as Blastomyces dermatitidis, Histoplasma capsulatum, and Sporothrix schenckii. The substance also shows some activity against various isolates of Aspergillus species.Клиническое использование
Amorolfine is the only drug in this class that is employed clinically in the treatment of human fungal infections. Amorolfine is not currently available in the United States, but it is marketed in Europe and Asia for the topical treatment of dermatophytic infections.Аморолфин запасные части и сырье
Аморолфин поставщик
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China | 22787 | 58 |