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Парафлутизид
- английское имяparaflutizide
- CAS №1580-83-2
- CBNumberCB3875049
- ФормулаC14H13ClFN3O4S2
- мольный вес405.85
- EINECS216-426-7
- номер MDLMFCD00867338
- файл Mol1580-83-2.mol
химическое свойство
Температура плавления | 238-240° |
Температура кипения | 636.2±65.0 °C(Predicted) |
плотность | 1.571±0.06 g/cm3(Predicted) |
пка | 8.66±0.40(Predicted) |
FDA UNII | 53A5V9FGN9 |
Парафлутизид химические свойства, назначение, производство
Создатель
Paraflutizide, Shanghai LanshengПроизводственный процесс
A mixture of 5.0 g (0.0357 g/mol) of ρ-fluorophenylethyl alcohol, 2.0 g (0.007 g/mol) of 5-chloro-2,4-disulphamylaniline, 2.0 g (0.0068 g/mol) of potassium bichromate and 15 ml of concentrated hydrochloric acid (0.176 g/mol) and 25 ml of water is heated under reflux for 1 h. The mixture is allowed to cool, and 15 ml of ether are added to separate the excess of ρ-fluorophenylethyl alcohol. The aqueous layer is decanted and frozen for 2 h and the precipitate is separated, washed with water and dried in vacuum over phosphoric anhydride. There are collected 1.35 g (yield 47.5%) of the 1,1-dioxide of 3-ρfluorophenyl-methyl-7-sulphamyl-6-chloro-3,4-dihydrobenzo-1,2,4-thiadiazine, which when recrystallised from 30 ml of 50% alcohol on "Norit" active carbon takes the form of a white crystalline substance, melting point is 239°C.Терапевтическая функция
DiureticПарафлутизид запасные части и сырье
Парафлутизид поставщик
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