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Amentoflavone
- русский язык имя
- английское имяAmentoflavone
- CAS №1617-53-4
- CBNumberCB3744024
- ФормулаC30H18O10
- мольный вес538.46
- EINECS-0
- номер MDLMFCD00017470
- файл Mol1617-53-4.mol
химическое свойство
Температура плавления | >300°C (dec.) |
Температура кипения | 910.5±65.0 °C(Predicted) |
плотность | 1.656±0.06 g/cm3(Predicted) |
температура хранения | Inert atmosphere,2-8°C |
растворимость | DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly) |
пка | 6.01±0.40(Predicted) |
форма | Solid |
цвет | Yellow |
БРН | 380244 |
ИнЧИКей | YUSWMAULDXZHPY-UHFFFAOYSA-N |
LogP | 3.492 (est) |
Справочник по базе данных CAS | 1617-53-4(CAS DataBase Reference) |
FDA UNII | 9I1VC79L77 |
Amentoflavone химические свойства, назначение, производство
Описание
Amentoflavone is a biflavonoid originally isolated from Selaginella. It has a wide variety of biological effects including antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities. Amentoflavone has antiviral activity against the influenza A subtypes H1N1 and H3N2, influenza B, and herpes simplex virus 1 (EC50s = 3.1 and 4.3, 0.56, and 17.9 μg/ml, respectively). It has antidiabetic effects such that it dose-dependently increases insulin receptor phosphorylation and activation and inhibits hydrolysis of p-nitrophenyl phosphate (p-NPP) catalyzed by protein tyrosine phosphatase 1B (PTP1B; IC50 = 7.3 μM). Amentoflavone reduces the time mice spend immobile in the forced swim test, a measure of antidepressant efficacy, in a dose-dependent manner.Биохимия/физиол Действия
Biflavonoid with anti-inflammatory, anti-viral and cancer chemopreventive activity. It inhibits vascularization of tumors by blocking the activity of angiogenic VEGFs. Blocks the induction of COX-2 and up-regulates PPAR-γ. It is a negative modulator of the GABAA receptor at the benzodiazepine binding site.Amentoflavone запасные части и сырье
запасной предмет
Amentoflavone поставщик
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