H-7 дигидрохлорид
- английское имяH-7 DIHYDROCHLORIDE
- CAS №108930-17-2
- CBNumberCB3725838
- ФормулаC14H19Cl2N3O2S
- мольный вес364.29
- номер MDLMFCD00036961
- файл Mol108930-17-2.mol
химическое свойство
| Температура плавления | 215-225 °C |
| температура хранения | 2-8°C |
| растворимость | H2O: 20 mg/mL |
| форма | Light yellow lyophilized solid |
| цвет | White to Off-White |
| БРН | 5840763 |
| Справочник по базе данных CAS | 108930-17-2(CAS DataBase Reference) |
| FDA UNII | 55VT8U9HB1 |
H-7 дигидрохлорид химические свойства, назначение, производство
Химические свойства
White Crystalline SolidИспользование
H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.Определение
ChEBI: A hydrochloride salt prepared from anileridine and two molar equivalents of hydrogen chloride.Общее описание
A broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (Ki = 97 μM), protein kinase A (Ki = 3.0 μM), protein kinase C (Ki = 6 μM), and protein kinase G (Ki = 5.8 μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.H-7 дигидрохлорид поставщик
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