H-7 дигидрохлорид

Химические свойства

White Crystalline Solid

Использование

H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.

Определение

ChEBI: A hydrochloride salt prepared from anileridine and two molar equivalents of hydrogen chloride.

Общее описание

A broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (K_i = 97 μM), protein kinase A (K_i = 3.0 μM), protein kinase C (K_i = 6 μM), and protein kinase G (K_i = 5.8 μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.