N-NITROSOMORPHOLINE

Химические свойства

yellow crystals or gold liquid

Использование

N-Nitrosomorpholine, a frequently used genotoxic model carcinogen. Toxicogenomic analysis of N-Nitrosomorpholine induced changes in rat liver.

Определение

ChEBI: A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco.

Общее описание

Yellow crystals. Golden liquid with many crystals at 68°F.

Реакции воздуха и воды

Water soluble.

Профиль реактивности

N-NITROSOMORPHOLINE is incompatible with strong oxidizing agents .

Угроза здоровью

ACUTE/CHRONIC HAZARDS: When heated to decomposition N-NITROSOMORPHOLINE emits toxic fumes of nitrogen oxides.

Пожароопасность

Flash point data for N-NITROSOMORPHOLINE are not available; however, N-NITROSOMORPHOLINE is probably combustible.

Профиль безопасности

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by inhalation. Human mutation data reported. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.

Канцерогенность

N-Nitrosomorpholine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.