БЕНЗТРОПИН МЕЗИЛАТ
- английское имяBenztropine mesylate
- CAS №132-17-2
- CBNumberCB2742553
- ФормулаC22H29NO4S
- мольный вес403.53
- EINECS205-048-8
- номер MDLMFCD00074784
- файл Mol132-17-2.mol
химическое свойство
| Температура плавления | 135 °C(lit.) |
| температура хранения | Inert atmosphere,2-8°C |
| растворимость | H2O: soluble20mg/mL, clear |
| форма | powder |
| цвет | white to beige |
| Растворимость в воде | Soluble in water (81 mg/ml at 25°C), DMSO (50 mg/ml at 25°C), ethanol (81 mg/ml at 25°C), and ether (very slightly). |
| Стабильность | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| LogP | 4.962 (est) |
| Справочник по базе данных CAS | 132-17-2(CAS DataBase Reference) |
| FDA UNII | WMJ8TL7510 |
| Коды опасности | T | |||||||||
| Заявления о рисках | 23/24/25 | |||||||||
| Заявления о безопасности | 36/37/39-45 | |||||||||
| РИДАДР | UN 2811 6.1/PG 3 | |||||||||
| WGK Германия | 3 | |||||||||
| RTECS | YM3150000 | |||||||||
| Класс опасности | 6.1 | |||||||||
| кода HS | 2939800000 | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H302：Вредно при проглатывании.
H311+H331：Токсично при попадании на кожу или при вдыхании.
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оператор предупредительных мер
P261：Избегать вдыхания пыли/ дыма/ газа/ тумана/ паров/ аэрозолей.
P264：После работы тщательно вымыть кожу.
P280：Использовать перчатки/ средства защиты глаз/ лица.
P301+P312：ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P302+P352+P312：ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды. Обратиться за медицинской помощью при плохом самочувствии.
P304+P340+P311：ПРИ ВДЫХАНИИ: Свежий воздух, покой. Обратиться за медицинской помощью.
БЕНЗТРОПИН МЕЗИЛАТ химические свойства, назначение, производство
Химические свойства
Benztropine mesylate is a synthetic compound containing structural features found in atropine and diphenhydramine.Benztropine mesylate is a crystalline white powder, very soluble in water, and has a molecular weight of 403.54. COGENTIN (benztropine mesylate) is supplied as a sterile injection for intravenous and intramuscular use.
Использование
Benztropine mesylate is an anti-histamine and dopamine re-uptake inhibitor. It has been used to study its target identification and mode of action against ebolavirus infection. It has also been used in pharmacological animal studies to evaluate its effect on SLC6A19 (solute carrier family 6 member 19; B0AT1).Определение
ChEBI: The methanesulfonate salt of benzatropine. An acetylcholine receptor antagonist, it is used in the treatment of Parkinson's disease, and to reduce parkinsonism and akathisia side effects of antipsychotic treatments.Общее описание
Benztropine mesylate,3α-(diphenylmethoxy)-1αH,5αH-tropane methanesulfonate(Cogentin), has anticholinergic, antihistaminic, and localanesthetic properties. Its anticholinergic effect makes it applicableas an antiparkinsonian agent. It is about as potent ananticholinergic as atropine and shares some of the side effectsof this drug, such as mydriasis and dryness of mouth.Importantly, however, it does not produce central stimulationbut instead exerts the characteristic sedative effect ofthe antihistamines.Биологическая активность
Benztropine mesylate is a centrally acting muscarinic acetylcholine receptor antagonist and dopamine transporter (DAT) inhibitor (IC50 = 118 nM). Benztropine mesylate has been used to treat the symptoms of Parkinson′s disease and is currently in clincial trials for chronic back pain.Benztropine mesylate serves as an inhibitor of breast cancer stem cells (BCSCs) in vitro and in vivo. It can help in improving the efficacy of chemotherapy in vitro. It is considered as an anti-cancer stem cell (CSC) drug, which can modify tumorigenic properties.
Клиническое использование
The tremor and rigidity characteristic of parkinsonismare relieved by benztropine mesylate, and it is particularlyvaluable for those patients who cannot tolerate central excitation(e.g., aged patients). It may also have a useful effectin minimizing drooling, sialorrhea, masklike facies, oculogyriccrises, and muscular cramps.The usual caution exercised with any anticholinergic inglaucoma and prostatic hypertrophy is observed with thisdrug.
Профиль безопасности
Poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. Human systemic effects by ingestion: psychotropic effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also ETHERS.БЕНЗТРОПИН МЕЗИЛАТ запасные части и сырье
БЕНЗТРОПИН МЕЗИЛАТ поставщик
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