N-АЦЕТИЛ-2- (4-НИТРОФЕНИЛ) ЭТИЛАМИН

Химические свойства

Pale yellow powder

Использование

N-ACETYL-2-(4-NITROPHENYL)ETHYLAMINE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Синтез

450Kg of concentrated sulfuric acid was added to the reactor, the temperature of the reaction solution was room temperature, the reaction solution containing the intermediate 1 was slowly added dropwise, and after sufficient stirring, 75 kg of 70% nitric acid was slowly added. After stirring until completion of the reaction, 800kg of crushed ice was added to the reaction solution and stirred constantly , Finally, pH was adjusted to 7~8 with ammonia solution to give crude product after filtration, crude product was recrystallized from methyl ethyl ketone to give 140 Kg of Intermediate 2, with a yield of 81.5%.