20ALPHA-HYDROXYCHOLESTEROL
- русский язык имя
- английское имя20ALPHA-HYDROXYCHOLESTEROL
- CAS №516-72-3
- CBNumberCB2372501
- ФормулаC27H46O2
- мольный вес402.65
- номер MDLMFCD16661190
- файл Mol516-72-3.mol
химическое свойство
| Температура плавления | 136-137°C |
| Температура кипения | 512.3±23.0 °C(Predicted) |
| плотность | 1.03±0.1 g/cm3(Predicted) |
| температура хранения | Inert atmosphere,2-8°C |
| растворимость | Soluble in DMSO or in Ethanol. |
| форма | Solid |
| пка | 15.04±0.70(Predicted) |
| цвет | White |
| Стабильность | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| FDA UNII | 30060WAL99 |
20ALPHA-HYDROXYCHOLESTEROL химические свойства, назначение, производство
Описание
20(S)-hydroxy Cholesterol is an allosteric agonist of the smoothened (Smo) receptor that activates the hedgehog (Hh) signaling pathway with an EC50 value of approxiately 3 μM in a gene transcription reporter assay using NIH3T3 cells. 20(S)-hydroxy Cholesterol is necessary for normal Hh signaling. It induces Smo accumulation in primary cilia, an early event in signaling, and binds to the extracellular, cysteine-rich domain of Smo. 20(S)-hydroxy Cholesterol also stimulates osteogenic differentiation of pluripotent bone marrow stromal cells, a process mediated via Hh and Notch signaling.Химические свойства
White SolidИспользование
A metabolite of Cholesterol. Cholesterol oxidation product having cytotoxicity effectsОпределение
ChEBI: An oxysterol that is cholesterol substituted by a hydroxy group at position 20.20ALPHA-HYDROXYCHOLESTEROL запасные части и сырье
20ALPHA-HYDROXYCHOLESTEROL поставщик
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