E3 ligase Ligand-Linker Conjugates 3
- русский язык имя
- английское имяE3 ligase Ligand-Linker Conjugates 3
- CAS №2101200-09-1
- CBNumberCB23386471
- ФормулаC26H35N7O5S
- мольный вес557.67
- номер MDLMFCD31807301
- файл Mol2101200-09-1.mol
E3 ligase Ligand-Linker Conjugates 3 химические свойства, назначение, производство
Использование
Protein degrader builiding block (S,R,S)-AHPC-PEG1-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.E3 ligase Ligand-Linker Conjugates 3 поставщик
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