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A-967079
- английское имяA 967079
- CAS №1170613-55-4
- CBNumberCB22650391
- ФормулаC12H14FNO
- мольный вес207.24
- номер MDLMFCD20488058
- файл Mol1170613-55-4.mol
химическое свойство
Температура кипения | 324.4±34.0 °C(Predicted) |
плотность | 1.03±0.1 g/cm3 (20 ºC 760 Torr) |
температура хранения | 2-8°C |
растворимость | DMSO: ≥12mg/mL |
пка | 12.23±0.40(Predicted) |
форма | powder |
цвет | white to tan |
Стабильность | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months |
FDA UNII | S15N98QQ2K |
A-967079 химические свойства, назначение, производство
Использование
(1E,3E)- 1-(4-Fluorophenyl)-2-methyl-1-penten-3-one Oxime is a transient receptor potential ankyrin 1 (TRPA1) antagonist and has been investigated as potential analgesic drug for the treatment of chronic pain.Общее описание
A-967079 prevents neuropathic and inflammatory pain. It reduces cold allodynia, which is produced by nerve injury.Биохимия/физиол Действия
A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC50′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation.A-967079 поставщик
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