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Наратриптан
- английское имяNaratriptan
- CAS №121679-13-8
- CBNumberCB1874790
- ФормулаC17H25N3O2S
- мольный вес335.46
- номер MDLMFCD00866221
- файл Mol121679-13-8.mol
химическое свойство
Температура плавления | 170-171° |
Температура кипения | 541.3±60.0 °C(Predicted) |
плотность | 1.227±0.06 g/cm3(Predicted) |
пка | 11.52±0.40(Predicted) |
FDA UNII | QX3KXL1ZA2 |
Код УВД | N02CC02 |
Наратриптан химические свойства, назначение, производство
Использование
Naratriptan is a triptan drug that is used for the treatment of migraine headaches.Общее описание
Naratriptan, the third triptan approved in 1998, is one of themost lipophilic triptans marketed to date. It has a much improvedbioavailability (63% in men and 74% in women), agreater affinity for 5-HT1B/1D receptors (3–6 times), and alower recurrence rate than sumatriptan because of its muchlonger elimination half-life. Naratritan also has a favorableCNS side effect profile when compared with sumatriptanor zolmitriptan because of its metabolic stability,thereby lacking a N-demethylated active metabolite and asignificant renal excretion ( 70% of naratriptan is excretedunchanged and the rest of the administered dose is degradedvia several CYP isozymes).Наратриптан запасные части и сырье
Наратриптан поставщик
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