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Бутенафин
- английское имяButenafine
- CAS №101828-21-1
- CBNumberCB1742475
- ФормулаC23H27N
- мольный вес317.47
- номер MDLMFCD00865577
- файл Mol101828-21-1.mol
химическое свойство
Температура плавления | 200-202 °C |
Температура кипения | 426.1±14.0 °C(Predicted) |
плотность | 1.032±0.06 g/cm3(Predicted) |
температура хранения | Store at -20°C |
растворимость | DMSO: 63 mg/mL (198.44 mM);Ethanol: 63 mg/mL (198.44 mM) |
пка | 7.87±0.50(Predicted) |
Растворимость в воде | Water: Insoluble |
LogP | 6.770 (est) |
Справочник по базе данных CAS | 101828-21-1(CAS DataBase Reference) |
FDA UNII | 91Y494NL0X |
Код УВД | D01AE23 |
Бутенафин химические свойства, назначение, производство
Использование
Butenafine (Mentax) is a synthetic benzylamine antifungal agent, related structurally and pharmacologically to terbinafine. It is thought to act by inhibiting the enzyme squalene 2,3-epoxidase, resulting in decreased ergosterol and corresponding increase in squalene, with subsequent cell membrane permeability alteration and cell death. It is active against dermatophytes, yeast, and Sporothrix.![Butenafine (Mentax)](https://www.chemicalbook.com/NewsImg/2020-02-28/202022817542125707.jpg)
Определение
ChEBI: Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in funga cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections.Имя бренда
Lotrimin (Schering); Mentax (Mylan Bertek).Бутенафин поставщик
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