23-HYDROXYBETULINIC ACID
- русский язык имя
- английское имя23-HYDROXYBETULINIC ACID
- CAS №85999-40-2
- CBNumberCB1694435
- ФормулаC30H48O4
- мольный вес472.7
- номер MDLMFCD28126999
- файл Mol85999-40-2.mol
химическое свойство
| Температура плавления | >293°C (dec.) |
| Температура кипения | 585.8±25.0 °C(Predicted) |
| плотность | 1.106 |
| температура хранения | -20°C Freezer, Under inert atmosphere |
| растворимость | Methanol (Slightly, Heated), Pyridine (Slightly) |
| форма | Solid |
| пка | 4.60±0.70(Predicted) |
| цвет | White |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
23-HYDROXYBETULINIC ACID химические свойства, назначение, производство
Описание
23-hydroxy Betulinic acid is a triterpenoid that has been found in P. chinensis and has anticancer activity. It inhibits proliferation of K562, B16, and HeLa cells (IC50s = 39.9, 78.5, and 80 μM, respectively), as well as human umbilical vein endothelial cells (HUVECs; IC50 = 94.8 μM). It halts the cell cycle at the S phase and induces apoptosis in K562 cells in a concentration-dependent manner with a loss of the mitochondrial membrane potential and an increase in Bax and cytochrome C protein levels.Использование
23-Hydroxybetulinic Acid is a potential cytoxic agent in the treatment of cancer. Apoptotic effect. Antiproliferative.23-HYDROXYBETULINIC ACID поставщик
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