1-Хлор-2-иодэтан

Использование

1-Chloro-2-iodoethane is used as a mild electrophile for iodination of metallated species, as in the conversion of an ortho-lithiated benzyl ether to the corresponding ortho-iodide. It reacts with 5-hydroxy-[1,4]naphthoquinone, and obtain the 5-(2-chloro-ethoxy)-[1,4]naphthoquinone.

Подготовка

The Preparative Methods of 1-chloro-2-iodoethane: prepared in 76% yield by bubbling Ethylene gas into a CH2Cl2 solution of freshly redistilled Iodine Monochloride maintained at 30 °C by ice-cooling until the temperature begins to fall. Other methods of preparation include reaction of ethylene, Copper(II) Chloride, and Iodine at 75-85 °C in a pressure reactor; reaction of excess 1,2-dichloroethane with Sodium Iodide in acetone or with Aluminum Iodide in CS2; and by reaction of 2-iodoethanol with Thionyl Chloride.