ANGIOTENSIN III, HUMAN

Описание

Angiotensin III (Ang III) is a heptapeptide agonist at the angiotensin 1 (AT₁) and AT₂ receptors, with a 30-fold higher affinity for AT₂ compared with AT₁ in HEK293 cells. Ang III is the preferred agonist for renal AT₂ receptors, which are responsible for sodium excretion into the urine. Ang III induces the same level of aldosterone synthesis as Ang II but has lower vasoconstrictive activity in vivo. In the brain renin-angiotensin system, Ang III increases sympathetic nerve activity and vasopressin release and dampens the baroreflex leading to higher blood pressure.