Оксапрозин

Описание

Oxaprozin is a non-steroidal antiinflammatory agent indicated for use in various forms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. A long T_1/2 allows once/twice daily dosing. Structurally it is somewhat unique, being a 3- substituted, rather than a 2-substituted propionic acid.

Химические свойства

White Solid

Использование

Oxaprozin is an anti-inflammatory drug. Oxaprozin was comparable to Aspirin (A687780).

Определение

ChEBI: A monocarboxylic acid that is a propionic acid derivative having a 4,5-diphenyl-1,3-oxazol-2-yl substituent at position 3. It is non-steroidal anti-inflammatory drug commonly used to relieve the pain and inflammatory responses associated with osteoarthrit s and rheumatoid arthritis.

Показания

Oxaprozin (Daypro) is approved for the treatment of osteoarthritis and rheumatoid arthritis. Its long halflife allows for once daily dosing.The most frequently reported adverse effects of this drug are nausea, vomiting, and dyspepsia.

Общее описание

Oxaprozin, 4,5-diphenyl-2-oxazolepropionic acid (Daypro),differs from the other members of this group in being anarylpropionic acid derivative. It shares the same propertiesand side effects of other members in this group. It is indicatedfor the short- and long-term management of OA andRA, administered as a once-daily dose of 600- to 1,200-mgdose because of its long duration of action.

Фармакокине?тика

Oxaprozin is well absorbed (100%) following oral administration, but maximum plasma concentrations are not reached until 3 to 5 hours following ingestion. Oxaprozin is an anti-inflammatory agent possessing a rapid onset of action and a prolonged duration of action. In both the carrageenan raw paw edema assay and analgetic tests, it was equipotent with aspirin. Oxaprozin has been associated with the appearance of rash and/or mild photosensitivity. Some patients experience an increased incidence of rash on sun-exposed skin during clinical testing.

Профиль безопасности

Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. An anti-inflammatory agent. When heated to decomposition it emits toxic fumes of NOx.