ДжЗЛ 184
- английское имяJZL 184
- CAS №1101854-58-3
- CBNumberCB12535677
- ФормулаC27H24N2O9
- мольный вес520.49
- файл Mol1101854-58-3.mol
химическое свойство
Температура плавления | 116-120°C |
Температура кипения | 706.4±60.0 °C(Predicted) |
плотность | 1.467±0.06 g/cm3(Predicted) |
температура хранения | 2-8°C |
растворимость | Soluble in DMSO (up to 25 mg/ml). |
форма | White to off-white solid |
пка | 13.32±0.29(Predicted) |
цвет | light yellow to yellow-green |
Стабильность | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months |
Справочник по базе данных CAS | 1101854-58-3 |
FDA UNII | 7MZ1I2J68A |
рисовальное письмо(GHS)
-
рисовальное письмо(GHS)
-
сигнальный язык
опасность
-
вредная бумага
H301:Токсично при проглатывании.
-
оператор предупредительных мер
P301+P310:ПРИ ПРОГЛАТЫВАНИИ: Немедленно обратиться за медицинской помощью. Прополоскать рот.
ДжЗЛ 184 химические свойства, назначение, производство
Описание
Endocannabinoids such as 2-Использование
JZL 184 hydrate has been used as an inhibitor of monoacylglycerol lipase to study its effect on human osteoblast differentiation and proliferation and postsynaptic neurons.Биохимия/физиол Действия
JZL184 selectively inhibits MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG). Anandamide and 2-AG are the two endogenous endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Anandamide is predominantly metabolized by fatty acid amide hydrolase (FAAH), whereas monoacylglycerol lipase (MAGL) is thought to be the enzyme primarily responsible for the degradation of 2-AG. It is difficult to separate the activities of the two because most currently available inhibitors of MAGL are not selective, and also inhibit FAAH or other enzymes. JZL 184 is the first selective inhibitor of MAGL with nanomolar portency and over 200-fold selectivity for MAGL vs FAAH. When administered to mice, JZL184 increased levels of 2-arachidonoylglycerol in the brain by about 8-fold, with no effect on levels of anandamide.ДжЗЛ 184 поставщик
поставщик | телефон | страна | номенклатура продукции | благоприятные условия |
---|---|---|---|---|
+undefined-21-51877795 | China | 32760 | 60 | |
+86-0371-86658258 +8613203830695 |
China | 29826 | 58 | |
86-571-88216897,88216896 13588875226 |
CHINA | 6313 | 58 | |
+8615056975894 | CHINA | 9923 | 58 | |
+1-708-310-1919 +1-13798911105 |
United States | 6393 | 58 | |
+86-852-30606658 | China | 24738 | 58 | |
+1-781-999-5354 | United States | 19973 | 58 | |
13417589054 | China | 11681 | 58 | |
+8618327326525 | China | 8474 | 58 | |
+1-+1(833)-552-7181 | United States | 57511 | 58 |