4-нитрохинолин-N-оксид

Химические свойства

yellow-brown crystals or powder

Использование

4-Nitroquinoline N-Oxide is used in method for constructing animal model of oral mucosal malignancy related to Kras mutation.

Определение

ChEBI: A quinoline N-oxide carrying a nitro substituent at position 4.

Общее описание

Yellowish-brown plates or needles or yellow solid.

Реакции воздуха и воды

4-NITROQUINOLINE N-OXIDE is hygroscopic and light sensitive. Insoluble in water.

Профиль реактивности

4-NITROQUINOLINE N-OXIDE reacts with strong oxidizing agents.

Угроза здоровью

ACUTE/CHRONIC HAZARDS: 4-NITROQUINOLINE N-OXIDE may cause irritation. When heated to decomposition it may emit toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides.

Пожароопасность

Flash point data for 4-NITROQUINOLINE N-OXIDE are not available; however, 4-NITROQUINOLINE N-OXIDE is probably combustible.

Профиль безопасности

Suspected carcinogen with experimental carcinogenic, neoplas tigenic, and tumorigenic data. Poison by intraperitoneal and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Методы очистки

The N-oxide recrystallises from aqueous acetone as yellow needles or platelets. [Ochiai J Org Chem 18 534 1953, Seki et al. J Phys Chem 91 126 1987, Beilstein 20 III/IV 3396.]