Рутамицин
- английское имяRutamycin
- CAS №1404-59-7
- CBNumberCB11120704
- ФормулаC44H72O11
- мольный вес777.042
- номер MDLMFCD32640222
- файл Mol1404-59-7.mol
химическое свойство
| Температура плавления | 116-119° |
| альфа | D20 -62° (c = 1.36 in CHCl3) |
| Температура кипения | 883.4±65.0 °C(Predicted) |
| плотность | 1.15±0.1 g/cm3(Predicted) |
| температура хранения | Store at -20°C |
| растворимость | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble |
| форма | A lyophilisate |
| пка | 12.52±0.70(Predicted) |
| Рейтинг продуктов питания EWG | 1 |
| FDA UNII | 4736R46V0G |
| РИДАДР | 2811 |
| Класс опасности | 6.1(b) |
| Группа упаковки | III |
| Токсичность | LD50 oral in mouse: 800mg/kg |
Рутамицин химические свойства, назначение, производство
Описание
Oligomycin D is a macrolide antibiotic produced by several species of Streptomyces that inhibits the mitochondrial F1FO-ATPase and is used to uncouple oxidative phosphorylation from electron transport. Oligomycin D is reported to inhibit K-Ras plasma membrane localization in MDCK cells with an IC50 value of 3.49 nM and is cytotoxic to SW620 colon cancer cells with an IC50 value of 36 μM.Использование
Oligomycin D (rutamycin) is macrocyclic lactone belonging to the oligomycin class but identified from different species of Streptomyces in 1961. Like oligomycin A, oligomycin D inhibits mitochondrial F1F0-ATPase and is an important bioprobe to study the organisation of ATPase on the mitochondrial membrane. Oligomycin D exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.Рутамицин поставщик
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