Бетанидин

Создатель

Bendogen,Lagap Pharmaceuticals SA

Производственный процесс

A mixture of 2-bromobenzylamine (12.5 g) and S-methylthiouronium sulfate (10 g) in water (20 ml) was heated for 1.5 hours on a steam bath in a hood, during which methylmercaptan escaped (as evidenced by a foul odour). The reaction mixture was then cooled and diluted with ethanol (100 ml). A colourless solid of 2-bromobenzylguanidine sulfate was separeted, and washed with ethanol. This solid melted at 230-232°C; it was recrystallized from water and then melted at 247-248°C. By action of a basic agent the salt obtained may be converted into free base.

Терапевтическая функция

Antihypertensive