Ипрониазид
- английское имяiproniazid
- CAS №54-92-2
- CBNumberCB0928533
- ФормулаC9H13N3O
- мольный вес179.22
- EINECS200-218-8
- номер MDLMFCD00153819
- файл Mol54-92-2.mol
химическое свойство
| Температура плавления | 112.5-113.5° |
| Температура кипения | 311.75°C (rough estimate) |
| плотность | 1.1305 (rough estimate) |
| показатель преломления | 1.5100 (estimate) |
| температура хранения | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| растворимость | DMSO (Slightly), Methanol (Slightly) |
| форма | Solid |
| пка | 11.28±0.23(Predicted) |
| цвет | Pale Beige |
| Справочник по базе данных CAS | 54-92-2 |
| FDA UNII | D892HFI3XA |
| кода HS | 2933399990 |
| Токсичность | An isopropyl derivative of isoniazid that was found to have mood-elevating effects in tuberculosis patients. It was later found to be a monoamine oxidase (MAO) inhibitor and, although not currently approved for clinical use as an antidepressant due to its propensity to cause liver damage it led to the development of other MAO inhibitors currently in use. In addition to hepatotoxic effects, iproniazid is a hypotensive agent and can cause potentially hazardous reactions with other drugs and amine-rich foods. |
рисовальное письмо(GHS)
-
рисовальное письмо(GHS)
-
сигнальный язык
предупреждение
-
вредная бумага
H302：Вредно при проглатывании.
-
оператор предупредительных мер
P264：После работы тщательно вымыть кожу.
P270：При использовании продукции не курить, не пить, не принимать пищу.
P301+P312+P330：ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии. Прополоскать рот.
P501：Удалить содержимое/ контейнер на утвержденных станциях утилизации отходов.
Ипрониазид химические свойства, назначение, производство
Использование
Iproniazid is a hydrazine based drug used as an antidepressant. Iproniazid acts as an irreversible and nonselective monoamine oxidase inhibitor.Всемирная организация здравоохранения(ВОЗ)
Iproniazid, a monoamine oxidase inhibitor (MAOI), was introduced in 1952 for the treatment of depressive illness. Subsequently concern regarding potentially serious interactions between MAOIs and foods containing tyramine inspired much restrictive regulatory action. However, MAOIs still retain a place in the treatment of serious depressive illness although there is no international consensus on which compounds should be preferred. Thus iproniazid remains available in several countries.Методы очистки
Crystallise it from *benzene or *benzene /pet ether and dry it in a vacuum. It is soluble in H2O and EtOH. [Fox & Gibas J Org Chem 18 994 1953.] The dihydrochloride has m 227-228o (from EtOH). [Beilstein 22 III/IV 551.] It is an antidepressant.Ипрониазид поставщик
| поставщик | телефон | страна | номенклатура продукции | благоприятные условия |
|---|---|---|---|---|
| +86-021-57951555 +8617317452075 |
China | 1803 | 55 | |
| +undefined-21-51877795 | China | 32965 | 60 | |
| +1-858-6993322 | United States | 18526 | 58 | |
| +86-0371-86658258 +8613203830695 |
China | 29809 | 58 | |
| +1-781-999-5354 +1-00000000000 |
United States | 32161 | 58 | |
| +8615255079626 | China | 23541 | 58 | |
| China | 12341 | 58 | ||
| +1-708-310-1919 +1-13798911105 |
United States | 6391 | 58 | |
| +86-25-58393656 | China | 6854 | 58 | |
| +86-89586680 +86-13289823923 |
China | 8670 | 58 |