ZSTK474
- русский язык имя
- английское имяZSTK474
- CAS №475110-96-4
- CBNumberCB0505419
- ФормулаC19H21F2N7O2
- мольный вес417.41
- номер MDLMFCD08705334
- файл Mol475110-96-4.mol
химическое свойство
| Температура плавления | 217-219 °C(Solv: ethanol (64-17-5)) |
| Температура кипения | 640.3±65.0 °C(Predicted) |
| плотность | 1.57 |
| температура хранения | -20°C |
| растворимость | Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 2.5 mg/ml with warming). |
| форма | White powder. |
| пка | 5.21±0.10(Predicted) |
| цвет | White or off-white |
| Стабильность | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| FDA UNII | K0068GK39A |
ZSTK474 химические свойства, назначение, производство
Использование
ZSTK474 is a triazine derivative that acts as an inhibitor of class I phosphatidylinositol 3-kinase (PI3K) isoforms (IC50s = 17, 53, and 6 nM for p110β, -γ, and -δ, respectively). It is selective for PI3K, as it has negligible activity against 139 other kinases when tested at 30 μM. ZSTK474 is orally bioavailable and shows strong antitumor activity against human cancer xenografts in mice. The efficacy of ZSTK474 against certain cancer cells and tumors can be enhanced by combination therapy.Определение
ChEBI: A triamino-1,3,5-triazine that is 1,3,5-triazine in which two of the hydrogens have been replaced by morpholin-4-yl groups while the third hydrogen has been replaced by a 2-(difluoromethyl)benzimidazol-1-yl group. It is an inhibitor of phosphatidylinositol 3-kinase.ZSTK474 поставщик
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