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1-нафтол
- английское имя1-Naphthol
- CAS №90-15-3
- CBNumberCB0279325
- ФормулаC10H8O
- мольный вес144.17
- EINECS201-969-4
- номер MDLMFCD00003930
- файл Mol90-15-3.mol
Температура плавления | 94-96 °C(lit.) |
Температура кипения | 278-280 °C(lit.) |
плотность | 1.224 |
плотность пара | 4.5 (120 °C, vs air) |
давление пара | 1 mm Hg ( 94 °C) |
показатель преломления | 1.6224 |
Fp | 125 °C |
температура хранения | Store below +30°C. |
растворимость | Soluble in benzene, chloroform, ether and ethanol. |
пка | 9.34(at 25℃) |
форма | Crystalline Flakes |
цвет | white to off-white |
Запах | Slight phenolic odor |
Пределы взрываемости | 5% |
Растворимость в воде | 436.7mg/L(25 ºC) |
λмакс | 324nm(MeOH)(lit.) |
Чувствительный | Air & Light Sensitive |
Мерк | 14,6383 |
БРН | 1817321 |
Стабильность | Stable, but air and light sensitive - store under inert gas. Incompatible with strong bases, strong oxidizing agents. |
ИнЧИКей | KJCVRFUGPWSIIH-UHFFFAOYSA-N |
LogP | 2.84 at 25℃ |
Справочник по базе данных CAS | 90-15-3(CAS DataBase Reference) |
Рейтинг продуктов питания EWG | 4-8 |
FDA UNII | 2A71EAQ389 |
Справочник по химии NIST | 1-Naphthalenol(90-15-3) |
Система регистрации веществ EPA | 1-Naphthol (90-15-3) |
Коды опасности | Xn,N | |||||||||
Заявления о рисках | 21/22-37/38-41-51/53 | |||||||||
Заявления о безопасности | 22-26-37/39-2-61 | |||||||||
РИДАДР | UN 2811 6.1/PG 3 | |||||||||
WGK Германия | 1 | |||||||||
RTECS | QL2800000 | |||||||||
F | 8-23 | |||||||||
Температура самовоспламенения | 510 °C | |||||||||
TSCA | Yes | |||||||||
Класс опасности | 6.1 | |||||||||
Группа упаковки | III | |||||||||
кода HS | 29071510 | |||||||||
Банк данных об опасных веществах | 90-15-3(Hazardous Substances Data) | |||||||||
Токсичность | LD50 orally in Rabbit: 1870 mg/kg LD50 dermal Rabbit 880 mg/kg | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H315:При попадании на кожу вызывает раздражение.
H335:Может вызывать раздражение верхних дыхательных путей.
H302:Вредно при проглатывании.
H318:При попадании в глаза вызывает необратимые последствия.
H317:При контакте с кожей может вызывать аллергическую реакцию.
H410:Чрезвычайно токсично для водных организмов с долгосрочными последствиями.
H311:Токсично при попадании на кожу.
H371:Может поражать органы (Глаза) в результате однократного воздействия.
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оператор предупредительных мер
P273:Избегать попадания в окружающую среду.
P280:Использовать перчатки/ средства защиты глаз/ лица.
P301+P312:ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P302+P352+P312:ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды. Обратиться за медицинской помощью при плохом самочувствии.
P305+P351+P338:ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
P308+P311:ПРИ подозрении на возможность воздействия обратиться за медицинской помощью.
1-нафтол химические свойства, назначение, производство
Описание
1-Naphthol, or α-naphthol, is a fluorescent organic compound with the formula C10H7OH. It is a white solid. It is an isomer of 2-naphthol differing by the location of the hydroxyl group on the naphthalene ring. The naphthols are naphthalene homologues of phenol, with the hydroxyl group being more reactive than in the phenols. Both isomers are soluble in simple alcohols, ethers, and chloroform. They are precursors to a variety of useful compounds. Naphthols (both 1 and 2 isomers) are used as biomarkers for livestock and humans exposed to polycyclic aromatic hydrocarbons.α-naphtol, combined with epichlorhydrine and sodium hydroxide to form alpha-naphtyl glycidyl ether, caused sensitization in one of three workers in a chemical plant.
Химические свойства
Pale grey to brown solid with an unpleasant phenol odour. Darkens in the presence of light. Evaporates with water vapour. Soluble in ethanol, ether, benzene, chloroform and alkali solutions, insoluble in water. Precipitates violet when exposed to ferric chloride. 1-Naphthol [90-15-3] a-naphthol, 1- naphthalenol, 1-hydroxynaphthalene, C10H8O, Mr 144.16, forms colorless prisms (from toluene) which darken on exposure to air or light. The compound is steam volatile and sublimable. 1-Naphthol is reduced by sodium in liquid ammonia to give 5,6,7,8-tetrahydro-1-naphthol and is oxidized by NaOCl – FeCl3 or I2–KI to give a violet color. It is chlorinated by phosphorus pentachloride at 150℃ to give 1-chloronaphthalene, by sulfuryl chloride to give 4- chloro-1-naphthol, or by Cl2–CH3COOH to give 2,4-dichloro-1-naphthol. Similarly bromine forms 2,4-dibromo-1-naphthol, and this reaction may be used quantitatively for titration. Nitration of 1-naphthol gives complex mixtures. The crude 2,4-dinitro derivative was used in the mid-1800s as an acid yellow dye comparable to picric acid. Sulfonation at 50℃ readily yields 1-naphthol-2,4-disulfonic acid. Nitrous acid gives mainly the 2-nitroso derivative, contaminated with the 4-nitroso isomer.Использование
1-Naphthol is used as a precursor in the manufacturing of various azo dyes and pharmaceuticals such as nadolol. It is used as biomarkers. It is used in analytical chemistry as Molisch's reagent (1-naphthol dissolved in ethanol) for checking the presence of carbohydrates. It plays an essential role with sodium hypobromite to detect the presence of arginine in proteins, which is called as Sakaguchi test.Подготовка
2-Isopropylnaphthalene can be used to synthesize 1-naphthol by oxidation via the hydroperoxide (Hock synthesis).Historically 1-naphthol was produced via caustic fusion of naphthalene-1-sulfonic acid, but this was superseded by the I.G. Farbenindustrie process involving hydrolysis of 1-naphthylamine with aqueous 22 % sulfuric acid at 200°C under pressure in a lead-lined autoclave. To obtain a purer product, Union Carbide developed a process based on catalytic oxidation of tetralin to 1-tetralol and 1-tetralone followed by dehydrogenation. The two-stage catalytic process is claimed to give an overall yield of 72% 1-naphthol, with an overall efficiency of 97%.
Определение
ChEBI: 1-naphthol is a naphthol carrying a hydroxy group at position 1. It has a role as a genotoxin and a human xenobiotic metabolite.прикладной
1-Naphthol is a hydroxyl-aromatic compound. It has been used as a prooxidant to analyze its ability to induce hemolysis in a zebrafish G6PD (glucose-6-phosphate dehydrogenase) deficiency model.Общее описание
1-Naphthol, a metabolite of carbaryl and naphthanlene. It is formed by spontaneous reaction from (1R, 2S)-Naphthalene epoxide followed to form 1, 4-Dihydroxynaphthalene.Опасность
Toxic by ingestion and skin absorption.Контактные аллергены
1-Naphthol can be used in dye manufacture and is classified as a hair dye. Combined with epichlorhydrin and NaOH to form alpha-naphthyl glycidyl ether, it caused sensitization in one of three workers in a chemical plant.Профиль безопасности
Poison by ingestion and intraperitoneal routes. Moderately toxic by skin contact. An experimental teratogen. Experimental reproductive effects. A severe eye and skin irritant. Mutation data reported. Ingestion of large amounts can cause nephritis, vomiting, diarrhea, circulatory collapse, anemia, convulsions, and death. Can cause kidney irritation and injury to cornea and lens of the eye. Combustible when exposed to heat or flame. When heated to decomposition it emits acrid smoke and irritating fumes.Синтез
To a 10 mL pressure vessel, aryl halide (1.00 mmol), copper (I) oxide (0.05 mol), ligand (0.05 mol), 3 M sodium hydroxide (2 mL), and organic solvent (2 mL) were added. The reaction mixture was irradiated at 160 °C for 10 min with strong stirring. The reaction mixture was allowed to cool to room temperature. The reaction mixture was filtered through a plug of celite in a fritted filter funnel and washed with ethyl acetate. The product was extracted using 30 mL of ethyl acetate for three times. The organic extract is washed three times with 10 mL water and two times with 10 mL of brine. The combined organic phases were dried over anhydrous MgSO4 and the solvent was removed under reduced pressure to afford 1-naphthol.Методы очистки
Sublime 1-naphthol, then crystallise it from aqueous MeOH (charcoal), aqueous 25% or 50% EtOH, *C6H6, cyclohexane, heptane, CCl4 or H2O. Dry it over P2O5 in vacuo. The 4-nitrobenzoate has m 143o (from EtOH). [Shizuka et al. J Am Chem Soc 107 7816 1985, Beilstein 8 H 596, 6 IV 4208.]1-нафтол запасные части и сырье
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