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PHENYL-D5-BORONIC ACID
- русский язык имя
- английское имяPHENYL-D5-BORONIC ACID
- CAS №215527-70-1
- CBNumberCB0121981
- ФормулаC6H7BO2
- мольный вес121.93
- номер MDLMFCD02093711
- файл Mol215527-70-1.mol
химическое свойство
Температура плавления | 217-220 °C(lit.) |
растворимость | Chloroform (Slightly), DMSO |
форма | solid |
цвет | White |
Стабильность | Hygroscopic |
InChI | InChI=1S/C6H7BO2/c8-7(9)6-4-2-1-3-5-6/h1-5,8-9H |
ИнЧИКей | HXITXNWTGFUOAU-RALIUCGRSA-N |
SMILES | B(C1C([H])=C([H])C([H])=C([H])C=1[H])(O)O |
Справочник по базе данных CAS | 215527-70-1 |
Коды опасности | Xn |
Заявления о рисках | 22 |
Заявления о безопасности | 36 |
WGK Германия | 3 |
кода HS | 2931900090 |
рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H302+H312+H332:Вредно при проглатывании, при попадании на кожу или при вдыхании.
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оператор предупредительных мер
P280:Использовать перчатки/ средства защиты глаз/ лица.
P362+P364:Снять всю загрязненную одежду и выстирать ее перед повторным использованием.
PHENYL-D5-BORONIC ACID химические свойства, назначение, производство
Использование
Phenylboronic Acid-d5 is the isotope labelled analog of Phenylboronic Acid; a compound used in the organic synthesis of various pharmaceutical goods.Синтез
A dry three-neck flask equipped with a rubber septum, an addition funnel equipped with a rubber septum, and a condenser was charged under nitrogen with magnesium turnings. To the addition funnel was added D5-bromobenzene (6.5 mL, 62 mmol) (Aldrich) dissolved in a 1:1 mixture of THF/toluene (31 mL). Grignard reagent formation was observed after about after about 1 mL of the contents of the addition funnel had been added to the magnesium turnings. The remaining bromobenzene solution was added dropwise over a period of about 1 h. After the addition was complete the reaction mixture was heated at 70° C. for 1 h. The reaction mixture was cooled to room temperature and added via a canulating needled to an addition funnel on a second three-neck flask containing a solution of triethylborate (B(OEt)3) (10.5 mL, 62 mmol) in toluene (10 mL) maintained at 0° C. The solution of the freshly prepared Grignard reagent was then added dropwise to the solution of triethylborate over a period of 1 h. The cooling bath was then removed and the reaction mixture was allowed to stir at room temperature for 15 h. The reaction mixture was quenched with 10% H2SO4 (30 mL) and stirred at room temperature for 1 h. The layers were separated and the organic layer was dried over Na2SO4. After removal of the solvent, addition of hexane precipitated the product as an off-white solid, which was collected by filtration and dried to afford Phenyl-d5-boronic acid. Its yield: 3.50 g, 45%.PHENYL-D5-BORONIC ACID запасные части и сырье
сырьё
1of2
запасной предмет
PHENYL-D5-BORONIC ACID поставщик
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