1H-Pyrido(2,1-b)quinazoline-8-carboxamide, N-(1-methyl-4-(3-pyridinyl) butyl)-1-oxo-

Description

Ro 23-3423 is a specific thromboxane synthetase inhibitor.

Uses

Ro 23-3423 is a thromboxane synthase inhibitor with an IC50 value of 0.33 μM for human platelet microsomal thromboxane synthase. Ro 23-3423 increases plasma levels of PGF and PGE2 in a dose-dependent manner, accompanied by a decrease in mean systemic arterial pressure and systemic vascular resistance. Ro 23-3423 can be used in the study of general anesthesia[1].

References

[1] Morel D R, et al. Dose-dependent effects of a pyridoquinazoline thromboxane synthetase inhibitor on arachidonic acid metabolites and hemodynamics during E. coli endotoxemia in anesthetized sheep[J]. Prostaglandins, 1987, 33(6): 879-902. DOI:10.1016/0090-6980(87)90116-x