What is benefits and synthesis of Glutathione(GSH)?

Glutathione(GSH) is a tripeptide (cysteine, glycine, and glutamic acid) found in surprisingly high levels—5 millimolar—concentrations in most cells. It is involved in the detoxification of both xenobiotic and endogenous compounds. It facilitates excretion from cells (Hg), facilitates excretion from body (POPs, Hg) and directly neutralizes (POPs, many oxidative chemicals). The synthesis of GSH from glutamate, cysteine, and glycine is catalyzed sequentially by two cytosolic enzymes, γ-glutamylcysteine synthetase (GCS) and GSH synthetase. This pathway occurs in virtually all cell types, with the liver being the major producer and exporter of GSH.

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