Unveiling the Potential of 3-Chloropyrazine-2-carbonitrile in Modern Chemistry

3-Chloropyrazine-2-carbonitrile is a white solid. Its molecular structure contains a chlorine atom and a cyano group, and it can participate in a variety of nucleophilic substitution reactions.

Application

Synthesis of Novel Pyrazinamide Derivatives Based on 3-Chloropyrazine-2-carboxamide

The starting compound 3-chloropyrazine-2-carboxamide was prepared via partial hydrolysis of the nitrile group of 3-chloropyrazine-2-carbonitrile (Fluorochem, Co., Hadfield, Derbyshire, UK). A mixture of concentrated (30%) hydrogen peroxide (29 mL) and water (195 mL) was prepared and alkalinized with an 8% (w/v) solution of sodium hydroxide to obtain a solution with pH 9. The carbonitrile (104 mmol) was then added portionwise into the heated (50 °C) mixture over a period of 30 min. The whole mass was stirred for an additional 2.5 h at 55 °C while the pH was periodically monitored and alternatively adjusted to the value of 9 by adding a few drops of 8% NaOH solution. The reaction mixture was cooled in a fridge to initiate crystallization. The crude product was recrystallized from ethanol. The yield of this reaction was approximately 80%.

Hazard Classes and Categories

Acute Tox. 4 (33.3%)

Acute Tox. 4 (33.3%)

Skin Irrit. 2 (100%)

Eye Irrit. 2A (100%)

Acute Tox. 4 (33.3%)

STOT SE 3 (100%)

Storage

3-Chloropyrazine-2-carbonitrile should be storaged under inert gas (nitrogen or Argon) at 2-8°C.

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