Mestanolone: mechanism of action, applications and safety

General Description

Mestanolone, a synthetic anabolic steroid, mimics natural androgens to enhance muscle mass, strength, and fat loss by binding to androgen receptors. Primarily used to treat male hypogonadism, it is also sought after for its performance-enhancing effects in bodybuilding. However, non-medical use is prohibited in many sports due to potential misuse and health risks. While research explores potential applications in women’s health, safety concerns include liver toxicity, cardiovascular complications, and testosterone suppression. Despite potential benefits in physical performance, careful consideration and professional medical consultation are essential due to known and potential risks associated with Mestanolone use.

Figure 1. Mestanolone

Mechanism of action

Mestanolone, a synthetic anabolic steroid, exerts its effects by imitating the actions of natural male hormones known as androgens. By binding to androgen receptors within the body's cells, it triggers a series of physiological responses leading to increased muscle mass, improved strength, and rapid fat loss. These effects are achieved through several mechanisms, including the promotion of protein synthesis, inhibition of protein breakdown, and regulation of fat metabolism. Mestanolone's anabolic properties make it particularly valuable in strength training and bodybuilding, where it can enhance physical performance and facilitate swift gains in muscle mass. Overall, by targeting androgen receptors and influencing various metabolic processes, Mestanolone contributes to the development of a more muscular and lean physique, making it a sought-after substance in the realm of athletic and physical enhancement. ¹

Applications

Mestanolone is an androgen and anabolic steroid (AAS) medication which is primarily used in the treatment of male hypogonadism and androgen deficiencies. It is a synthetic derivative of dihydrotestosterone (DHT), a naturally occurring androgen in the human body. Mestanolone is available in oral form and is sometimes used to treat androgen deficiencies in men, such as delayed puberty or other hormonal imbalances. In addition to its medical applications, Mestanolone has also been used in athletic and bodybuilding circles for its potential performance-enhancing effects. As an androgen and anabolic steroid, Mestanolone can promote muscle growth, increase strength, and improve athletic performance. However, it is important to note that the non-medical use of Mestanolone and other AAS medications is prohibited in many competitive sports and organizations due to their potential for misuse and adverse health effects. Furthermore, Mestanolone has been studied for potential use in the treatment of certain medical conditions in women, such as breast cancer and postmenopausal osteoporosis. Research in this area is ongoing, and the safety and efficacy of Mestanolone for these purposes have not been firmly established. In conclusion, Mestanolone is primarily used in the medical treatment of male androgen deficiencies, and it has also been utilized for potential performance-enhancing effects in non-medical settings. Ongoing research may reveal additional applications for this medication in the future. ²

Safety

Mestanolone is an anabolic steroid with androgenic properties. It is commonly used in bodybuilding and athletic performance enhancement due to its potential to increase muscle mass and strength. When considering the safety of Mestanolone, it's important to acknowledge the potential risks and side effects associated with its use. Although Mestanolone has a lower tendency for estrogenic side effects compared to other anabolic steroids, it still poses several health risks. These include liver toxicity, cardiovascular complications, and suppression of natural testosterone production. Additionally, common side effects may include acne, hair loss, and aggression. Long-term use or high doses of Mestanolone can significantly increase the risk of adverse effects. Moreover, the illicit nature of anabolic steroid use may expose individuals to additional dangers, such as purchasing counterfeit or contaminated products. In conclusion, while Mestanolone may offer benefits in terms of physical performance, its safety profile raises concerns regarding both short-term and long-term use. Individuals considering the use of Mestanolone should carefully weigh the potential benefits against the known and potential risks, and always consult with a qualified healthcare professional before use. ³

Reference

1. HARRIS LH. The protein anabolic action of mestanolone. J Clin Endocrinol Metab. 1961 Sep;21:1099-1105.

2. Mestanolone. Drug Enforcement Administration, 2023.

3. Patt M, Beck KR, Di Marco T, Jäger MC, González-Ruiz V, Boccard J, Rudaz S, Hartmann RW, Salah M, van Koppen CJ, Grill M, Odermatt A. Profiling of anabolic androgenic steroids and selective androgen receptor modulators for interference with adrenal steroidogenesis. Biochem Pharmacol. 2020 Feb;172:113781.

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