Carbaspirin Calcium: A Calcium Acetylsalicylate-Urea Complex for Effective Management of Fever, Pain, and Inflammation

General Description

Carbaspirin calcium is a complex of calcium acetylsalicylate and urea, exhibiting antipyretic, analgesic, and anti-inflammatory properties, along with the ability to inhibit platelet aggregation. Its mechanism involves blocking cyclooxygenase enzymes, reducing inflammatory mediators like prostaglandins and thromboxanes. Indicated for conditions such as fever, pain, and cardiovascular protection, Carbaspirin calcium offers rapid oral absorption and high bioavailability. Recommended adult doses range from 600 mg to 2400 mg daily, while children’s doses must be adjusted based on age. Precautions include avoiding use in patients with peptic ulcers, salicylate allergies, and those pregnant or breastfeeding.

Figure 1. Carbaspirin Calcium

Pharmacodynamics

Carbaspirin calcium is a white crystalline powder that exhibits a slightly bitter taste and is highly soluble in water. It is a complex of calcium acetylsalicylate and urea, sharing pharmacological characteristics with aspirin. The primary pharmacological actions of Carbaspirin calcium include antipyretic, analgesic, and anti-inflammatory effects. Additionally, it plays a crucial role in inhibiting platelet aggregation, thus preventing thrombosis caused by various factors. This multifaceted action makes Carbaspirin calcium an essential medication in managing pain and inflammation while also addressing cardiovascular issues.

Mechanism of Action

The mechanism of action of Carbaspirin calcium revolves around its ability to inhibit cyclooxygenase (COX) enzymes, which are vital for the synthesis of prostaglandins and thromboxanes. By blocking COX, Carbaspirin calcium effectively reduces the production of these inflammatory mediators, leading to decreased pain, fever, and inflammation. Furthermore, the inhibition of thromboxane A2 synthesis plays a significant role in reducing platelet aggregation, making Carbaspirin calcium beneficial for patients at risk of thrombotic events. This pharmacological versatility allows healthcare providers to use Carbaspirin calcium in various clinical settings, ranging from pain management to cardiovascular protection. ¹

Clinical Applications and Bioavailability

Carbaspirin calcium is indicated for a wide range of conditions, including fever caused by colds, headaches, dental pain, neuralgia, dysmenorrhea, and rheumatic diseases such as rheumatoid arthritis. Its effectiveness also extends to the prevention of transient ischemic attacks and myocardial infarction, as well as thrombosis after surgical procedures. One of the key advantages of Carbaspirin calcium is its rapid oral absorption and high bioavailability, which ensures quick onset of action. This is particularly beneficial in acute pain situations where prompt relief is desired. Moreover, Carbaspirin calcium undergoes metabolism in the liver and is excreted through the kidneys, further emphasizing its pharmacokinetic properties and overall therapeutic utility. ¹

Dosage

Carbaspirin calcium is a medication commonly used for its analgesic and antipyretic properties. It is particularly effective in treating mild to moderate pain, as well as reducing fever. The recommended administration for adults is oral, with an average dose being 600 mg three times a day. If necessary, doses can be repeated every four hours, but the total daily intake should not exceed 3.6 grams. For patients with rheumatic diseases, Carbaspirin calcium may be taken at a dosage determined by a healthcare professional, typically ranging from 600 mg to 2400 mg per day divided into multiple doses. For children, dosages vary significantly according to age, underscoring the importance of following medical advice for precise administration. ²

Precautions for Usage

While Carbaspirin calcium can be effective, there are important precautions to consider. Patients with a history of peptic ulcer disease, salicylate allergy, or any bleeding disorders should avoid using Carbaspirin calcium due to the increased risk of complications. It is also critical for pregnant and breastfeeding women to seek consultation from a healthcare provider before use. The first trimester of pregnancy is especially sensitive, and it is recommended to refrain from using Carbaspirin calcium, while its use is strictly prohibited during the last four weeks of pregnancy. Additionally, individuals with compromised liver or kidney function, asthma, excessive menstruation, and gout should proceed carefully when considering Carbaspirin calcium. ²

Dosage Forms and Recommendations

Carbaspirin calcium is available in a powdered formulation, with each packet containing 600 mg. Various dosages such as 0.05 g, 0.1 g, 0.15 g, 0.2 g, 0.3 g, and 0.6 g allow for tailored treatment depending on the patient's needs. It is essential for patients to adhere to the prescribed dosages and intervals to maximize the efficacy of Carbaspirin calcium while minimizing potential side effects. Before initiating treatment with Carbaspirin calcium, individuals currently on anticoagulant therapy should speak with their healthcare provider as the interaction may require careful monitoring. Overall, Carbaspirin calcium is a versatile medication, but responsible use is crucial for ensuring safety and effectiveness. ¹

Reference

1. Carbaspirin calcium. DrugBank. DrugBank Accession Number: DB13612.

2. National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 21975, Carbasalate calcium.

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