4-Bromofluorobenzene: Applications and Safety Profile

General Description

4-Bromofluorobenzene is a versatile compound with diverse applications. It is crucial in enhancing the performance of organic electroluminescent devices, improving display quality and operational lifespan. Additionally, it serves as a valuable building block in organic syntheses, aiding in the creation of complex molecular structures in pharmaceuticals and polymers. In analytical chemistry, 4-Bromofluorobenzene is utilized as a standard for precise determination of volatile organic compounds, ensuring accuracy in GC/MS analysis. However, its toxicological impacts necessitate stringent safety measures due to skin and eye irritation, sensitization potential, and systemic effects observed in exposure scenarios, emphasizing the need for careful handling protocols.

Figure 1. 4-Bromofluorobenzene

Applications

Application in Organic Electroluminescent Devices

4-Bromofluorobenzene finds innovative applications in the development of organic electroluminescent devices, particularly within the domain of novel organic electroluminescent compounds. The presence of 4-Bromofluorobenzene in these compounds enhances their luminescent properties, contributing to superior luminous efficiency and color purity which are critical for high-quality display and lighting technologies. As an integral component, 4-Bromofluorobenzene improves the operational lifespan and performance of organic electroluminescent devices, making it a valuable material in the manufacturing of advanced OLEDs (Organic Light Emitting Diodes). The unique chemical structure of 4-Bromofluorobenzene allows for the fine-tuning of electronic properties, thereby facilitating the creation of devices that not only offer exceptional display characteristics but also exhibit prolonged durability and efficiency. This makes 4-Bromofluorobenzene a key substance in pushing the boundaries of organic electronics, particularly in the context of next-generation display technologies. ¹

Utilization in Organic Syntheses

In the field of organic chemistry, 4-Bromofluorobenzene is extensively employed as a versatile building block. Its dual functional groups, bromine and fluorine, make it an exemplary candidate for various organic transformations, including complex cross-coupling reactions essential for constructing elaborate molecular structures. The ability of 4-Bromofluorobenzene to engage in both electrophilic and nucleophilic reactions enhances its utility across a wide range of applications, facilitating the synthesis of sophisticated pharmaceuticals, polymers, and performance chemicals. The strategic deployment of 4-Bromofluorobenzene in these synthetic processes underscores its invaluable contribution to the creation of high-value chemical products. ²

Role in Analytical Chemistry

4-Bromofluorobenzene is also integral as a tuning, internal, or surrogate standard in the methodology of gas chromatography/mass spectrometry (GC/MS) for the precise determination of volatile organic compounds (VOCs). Its inert nature and well-defined mass spectral characteristics render it ideal for calibrating GC/MS equipment, ensuring high precision in analytical outcomes. Such standardization is crucial for applications in environmental monitoring, forensic science, and industrial quality control. The use of 4-Bromofluorobenzene enhances the reliability and accuracy of analytical results, thereby playing an essential role in scientific and industrial settings where VOC detection and quantification are required. ³

Safety Profile

Toxicological Impacts

4-Bromofluorobenzene has been identified as a compound with significant toxicological concerns, primarily manifested through its effects when in contact with skin or inhaled. According to various studies, 4-Bromofluorobenzene is a skin and eye irritant, particularly noted in animal studies with rabbits showing immediate irritation upon exposure. Further testing in guinea pigs has shown that 4-Bromofluorobenzene can act as a mild skin sensitizer, with a 20% sensitization rate reported in the Magnusson and Kligman test. These sensitization effects indicate that 4-Bromofluorobenzene can potentially lead to allergic reactions, highlighting the need for adequate protective measures when handling.

Hazardous Effects and Handling Recommendations

The hazardous nature of 4-Bromofluorobenzene extends beyond irritation and sensitization, as acute exposure scenarios in rats have revealed more severe systemic effects. Inhalation or oral exposure to 4-Bromofluorobenzene has been linked with symptoms such as tremors, changes in motor activity, ataxia, and dyspnea, underscoring the compound's potential to impair normal physiological functions. Structurally similar compounds to 4-Bromofluorobenzene have been recognized as hepatotoxins and possible carcinogens, suggesting that extensive exposure could pose long-term health risks. Therefore, handling 4-Bromofluorobenzene requires strict adherence to safety protocols including the use of appropriate respiratory protection and protective clothing to minimize exposure and mitigate these significant health risks. ⁴

Reference

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4. National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 9993, 1-Bromo-4-fluorobenzene.

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