2-Chloro-5-Chloromethylpyridine: Applications in Agricultural Chemistry and its Green Synthesis

2-chloro-5-chloromethylpyridine(CCMP) is the shared key intermediate of the nicotinoids agricultural chemicals such as Provado, acetamiprid, Ti304, also be one of fine-chemical intermediate of current consumption maximum.

Applications in Agricultural Chemistry

2-Chloro-5-chloromethylpyridine is an important intermediate for pesticides and pharmaceuticals. For example: 2-Chloro-5-chloromethylpyridine is important for synthesis Neonicotinoid insecticide Important intermediates such as imidacloprid, thiacloprid, acetamiprid, and nitenpyram.

Green Synthesis

With 2-chloro-5-methyl pyridine as a raw material, an initiation reaction is carried out with trichloroisocyanuric acid through a chemical initiator or a light source under conditions of the temperature of 80-200 DEG C and an ordinary pressure or a micro negative pressure, after the reaction, 2-chloro-5-chloromethylpyridine is obtained through filtering Compared with a chlorine gas method with higher dangerousness, the method not only avoid the use of a solvent, but also omits neutralization, water washing and other processes in the traditional chlorination process, and avoids generation of waste water and acidic tail gas.

Reactions

Reacts with mild steel, galvanized steel / zinc producing hydrogen gas which may form an explosive mixture with air.

Segregate from alkalis, oxidizing agents and chemicals readily decomposed by acids, i.e. cyanides, sulfides, carbonates.

Hazards

Harmful if swallowed.

Causes burns.

Risk of serious damage to eyes.

May cause SENSITISATION by skin contact.

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