ChemicalBook > Articles Catagory List >API >1-methylimidazole-an-overview

1-Methylimidazole: An Overview

Oct 24，2024

1-Methylimidazole is a colorless to yellow liquid, with an amine-like odor. lt ismiscible with water. lt is a versatile intermediate used as a building block for active ingredients as well as in epoxy curing.

In the traditional medicine industry, imidazoles can be used as antiviral, anti-tumor drug can be used as agricultural bactericide, can be used as the composite material solidification agent, and the electronics processing and fabricating is with novel solderability preservative etc.

Article illustration

Uses

1-Methylimidazole is a derivative of imidazole that is utilized in the manufacture of such classes of items as pharmaceuticals, pesticides, ion-exchange resins, dye intermediates, textile auxiliaries, photographic chemicals, and corrosion inhibitors.

It is also used as a catalyst for manufacturing polyurethanes and a curing agent for epoxy resins. 1-Methylimidazole has been utilized in the synthesis of inorganic complexes, ionic liquids, and catalytic deprotonation reagents. The use of 1-methylimidazole in the preparation of GDP-hexanolamine for the purification of fucosyltransferases has been reported.

Preparation

1-Methylimidazole is prepared mainly by two routes industrially. The main one is acid-catalysed methylation of imidazole by methanol. The second method involves the Radziszewski reaction from glyoxal, formaldehyde, and a mixture of ammonia and methylamine.

);