EntransterTM-R4000是英格恩生物(Engreen Biosystem)最新研发合成的针对siRNA、microRNA、mimic、inhibitor、mRNA和shRNA等RNA的转染试剂。EntransterTM-R4000不仅可以转染小RNA,而且针对mRNA等长链RNA优化。由于纳米技术的应用,EntransterTM-R4000能做到高达90%的转染效率和60-90%的沉默效率,对难转染细胞和原代细胞也非常适用。
小RNA转染。包括siRNA转染,miRNA,mimic,inhibitor等。 长链的mRNA和shRNA转染,针对mRNA和长链的shRNA等RNA转染优化。 可转染动物细胞、昆虫细胞等,也可以转染原代细胞、悬浮细胞和原代细胞等传统难转染细胞。
纳米聚合物,转染效果优于脂质体转染试剂 高效转染,沉默效率高,可以达到90%以上的沉默效率 低细胞毒性,有血清转染,无须反复更换培养基 原代细胞、悬浮细胞和敏感细胞都能转。
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G-MDSC-derived exosomes attenuate collagen-induced arthritis by impairing Th1 and Th17 cell responses.(G-MDSC来源的外体和胶原诱导的关节炎研究)
Mol Ther Nucleic Acids. 2019 Sep 6;17:38-48. doi: 10.1016/j.omtn.2019.05.004. Epub 2019 May 22.(IF:5.919).
Circular RNA Expression Profiling and the Potential Role of
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miR125a-3p.(桥本甲状腺炎中cirRNA表达研究)
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Liraglutide inhibits the apoptosis of human nucleus pulposus cells
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pathway.(利拉鲁肽和人髓核细胞凋亡研究)
J Autoimmun. 2019 Aug;102:96-113. doi: 10.1016/j.jaut.2019.04.018. Epub 2019 May 23.(IF:7.543).
NF-κB-driven miR-34a impairs Treg/Th17 balance via targeting Foxp3.(mir-34a与Treg/Th17细胞平衡研究)
Cancer Lett. 2019 May 28;450:110-122. doi: 10.1016/j.canlet.2019.02.029. Epub 2019 Feb 18.(IF:6.491).
STAT3 inhibition enhances CDN-induced STING signaling and antitumor immunity.(Stat3抑制可增强CDN诱导的STING信号和抗肿瘤免.)
Chemosphere. 2019 May;223:165-170. doi: 10.1016/j.chemosphere.2019.01.169. Epub 2019 Feb 1.(IF:4.427).
Polychlorinated diphenyl sulfides can induce ROS and genotoxicity via the AhR-CYP1A1 pathway.(多氯代二苯硫醚可通过AHR-CYP1A1途径诱导活性氧和基因毒性.)
Leuk Lymphoma. 2019 Mar;60(3):772-781. doi: 10.1080/10428194.2018.1493727. Epub 2019 Jan 15.
Targeting the cross-talk between the hedgehog and NF-κB signaling
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Long noncoding RNA Pvt1 regulates the immunosuppression activity of
granulocytic myeloid-derived suppressor cells in tumor-bearing
mice.(LncRNA Pvt1与粒细胞源性骨髓抑制细胞的免疫抑制活性研究)