2-氨基噻唑 96-50-4

2-氨基噻唑简介

2-Aminothiazole is a heterocyclic amine featuring an thiazole core. It can also be considered a cyclic isothiourea. It possesses an odor similar to pyridine and is soluble in water, alcohols and diethyl ether. It is commonly used as a starting point for the synthesis of many compounds including sulfur drugs, biocides, fungicides, dyes and chemical reaction accelerators. 2-Aminothiazole can be used as a thyroid inhibitor in the treatment of hyperthyroidism and has antibacterial activity. Alternatively, its acid tartrate salt can be used. Recent studies using prion-infected neuroblastoma cell lines have suggested that aminothiazole may be used as a therapeutic drug for prion diseases.

2-氨基噻唑物化性质

外观与性状：淡棕色晶体或棕色粒状的固体 沸点：117 °C (15.002 mmHg) 熔点：91-93 °C(lit.) 闪点：117°C/15mm 水溶解性：100 g/L (20 ºC) 稳定性：Stable under normal temperatures and pressures. 储存条件：库房通风低温干燥,与硝酸,硫酸分开存放

安全信息

RTECS号： XJ2100000 安全说明： S26-S36/37-S39 危险类别码： R22; R36/37 WGK Germany： 3 危险品运输编码： 2811 海关编码： 2934999090 包装等级： I; II; III 危险品标志： Xn

生产方法及用途

生产方法

由硫脲与氯乙醛(或乙醇和氯气,或α,β二氯乙基乙醚)经环合而得。在反应器中加入热水、硫脲和α,β-二氯乙基乙醚。在搅拌下回流2h。冷却,经滴液漏斗加入氢氧化钠溶液,使溶液呈碱性,析出2-氨基噻唑晶体。然后加入乙醚使之溶解。分出醚层,用水洗涤后,以无水硫酸钠干燥,蒸出乙醚得粗品。用乙醇重结晶,得黄色晶体。产率为80%,熔点90℃。

用途

2-氨基噻唑主要用于合成硝基磺胺噻唑（Nitrosulfathiazole）、磺胺噻唑（Sulfathiazole）、琥磺噻唑（Sulfasuxidinum）、马来酰磺胺噻唑（Carbothiazol）、酞磺胺噻唑（Phthalylsulfathiazole）、克泻磺（Oxyquinoline)，还用作染料中间体。