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托吡卡胺

Tropicamide
1508-75-4
询价 25Kg/Drum 起订
湖北 更新日期:2020-11-10

九州通医药集团股份有限公司

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产品详情:

中文名称:
托吡卡胺
英文名称:
Tropicamide
CAS号:
1508-75-4
产品类别:
boshan

Tropicamide

Tropicamide Structure
Tropicamide structure
 
Common Name Tropicamide
CAS Number 1508-75-4 Molecular Weight 284.353
Density 1.2±0.1 g/cm3 Boiling Point 492.8±45.0 °C at 760 mmHg
Molecular Formula C17H20N2O2 Melting Point 98 °C
MSDS ChineseUSA Flash Point 251.8±28.7 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Tropicamide


Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist .Target: mAChRTropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. It is used to allow better examination of the lens, vitreous humor, and retina. Due to its relatively short duration of effect (4-8 hours), it is typically used during eye examinations such as the dilated fundus examination, but it may also be used before or after eye surgery. Cycloplegic drops are often also used to treat anterior uveitis, decreasing risk of posterior synechiae and decreasing inflammation in the anterior chamber of the eye [1-3].

Tropicamide Biological Activity

Description Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist .Target: mAChRTropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. It is used to allow better examination of the lens, vitreous humor, and retina. Due to its relatively short duration of effect (4-8 hours), it is typically used during eye examinations such as the dilated fundus examination, but it may also be used before or after eye surgery. Cycloplegic drops are often also used to treat anterior uveitis, decreasing risk of posterior synechiae and decreasing inflammation in the anterior chamber of the eye [1-3].
Related Catalog
Signaling Pathways >> GPCR/G Protein >> mAChR
Signaling Pathways >> Neuronal Signaling >> mAChR
Research Areas >> Neurological Disease
References

[1]. Lazareno, S., N.J. Buckley, and F.F. Roberts, Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol, 1990. 38(6): p. 805-15.

[2]. Hernandez, M., et al., Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol, 1993. 110(4): p. 1413-20.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 492.8±45.0 °C at 760 mmHg
Melting Point 98 °C
Molecular Formula C17H20N2O2
Molecular Weight 284.353
Flash Point 251.8±28.7 °C
Exact Mass 284.152466
PSA 53.43000
LogP 1.15
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.586
Storage condition 2-8°C
Water Solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3 mg/mL

 

 

Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302 + H312 + H332-H315-H317-H319-H335
Precautionary Statements P261-P280-P301 + P312 + P330-P305 + P351 + P338
Hazard Codes Xn:Harmful
Risk Phrases R20/21/22;R36/37/38;R42/43
Safety Phrases S22-S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS CY1487860
HS Code 2933399090

 Synthetic Route

Total: 1 Page
4-(Ethylaminomethyl)pyridine structure

4-(Ethylaminome...

CAS#:33403-97-3

~%

Tropicamide Structure

Tropicamide

CAS#:1508-75-4

Literature: DE960634 , ;
Acetyltropylic chloride structure

Acetyltropylic ...

CAS#:14510-37-3

 
4-(Ethylaminomethyl)pyridine structure

4-(Ethylaminome...

CAS#:33403-97-3

~%

Tropicamide Structure

Tropicamide

CAS#:1508-75-4

Literature: DE960634 , ;

 Precursor & DownStream

Precursor  2

 

  • 4-(Ethylaminomethyl)pyridine Structure CAS#:33403-97-3
    4-(Ethylaminome...
  • Acetyltropylic chloride Structure CAS#:14510-37-3
    Acetyltropylic ...
DownStream  4

 

  • 2-Phenylacrylic acid structure CAS#:492-38-6
    2-Phenylacrylic acid
  • Tropic acid structure CAS#:529-64-6
    Tropic acid
  • n-ethyl-n-(4-picolyl)atropamide structure CAS#:57322-50-6
    n-ethyl-n-(4-pi...
  • 4-(Ethylaminomethyl)pyridine structure
 

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Tropicamide;CAS 1508-75-4;

公司简介

九州通是一家以西药、中药、器械为主要经营产品,以医疗机构、批发企业、零售药店为主要客户对象,并为客户提供信息、物流等各项增值服务的大型企业集团。公司立足于医药健康行业,是中国医药商业领域具有全国性网络的少数几家企业之一,于2010年11月2日在上海证券交易所挂牌上市(股票简称:九州通,证券代码:600998),公司连续多年位列中国医药商业企业第四位,领跑中国民营医药商业企业,2020年位列《财富》(中文版)500强第100位。 九州通成立于1999年3月,总部位于湖北省武汉市。截止2020年9月30日,公司注册资本18.78亿元,总资产787.17亿元。实现营业收入803.20亿元,净利润21.41亿元,分别较上年同期增长9.46%和110.23%。扣除非经常性损益后归属于上市公司股东的净利润为12.52亿元,较上年同期增长45.12%。2019年公司实现营业收入994.97亿元,归属于上市公司股东的净利润17.81亿元,分别较上年同期增长14.19%和28.96%。员工两万五千余人。直营和加盟零售连锁药店1074家。

成立日期 (26年)
注册资本 1877663513
员工人数 500人以上
年营业额 ¥ 1亿以上
经营模式 贸易,工厂
主营行业 医药中间体,原料药,兽药原料,维生素类

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