ANTI-VEGF-C POLYCLONAL ANTIBODY

Anti-VEGF-C Polyclonal Antibody

询价 50ul 起订

上海更新日期：2024-11-22

上海水熊生物科技有限公司

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联系人：水熊生物

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产品详情:

中文名称：: ANTI-VEGF-C POLYCLONAL ANTIBODY

英文名称：: Anti-VEGF-C Polyclonal Antibody

产品类别：: 抗体

来源	用途	交叉反应性	理论分子量	实际分子量
Rabbit	WB, IHC	H, M, R	46kDa	47kDa

WB, Western blot; IP, Immunoprecipitation; IF, Immunofluorescence; IHC, Immunohistochemistry; ICC, Immunocytochemistry; FC, Flow Cytometry; ChIP, Chromatin Immunoprecipitation Assay; ChIP-seq, ChIP-sequencing.
H, Human; M, Mouse; R, Rat; C, Chicken; Cw, Cow; Dg, Dog; Gp, Guinea pig; Hm, Hamster; Hr, Horse; Mk, Monkey; Pg, Pig; Rb, Rabbit; S, Sheep; Z, Zebrafish; All, all species expected.
配套提供了Western一抗稀释液，可以用于Western检测或其它适当用途时的一抗稀释。
建议抗体使用时的稀释比例如下(实际使用时需根据抗原水平的高低作适当调整)：

WB	IP	IF	IHC	ICC	FC	ChIP	ChIP-seq
1:500-1:2000	-	-	1:100-1:200	1:100-1:200	-	-	-

抗体详细信息如下::

About this Antibody
Name	VEGFC Rabbit Polyclonal Antibody
Category	Rabbit Polyclonal Antibody (pAb); Primary antibody
Isotype	IgG
Purification method	Affinity purification
Positive samples	BT-474, MCF7, Mouse spleen, Rat liver
Cellular location	Secreted
Customer validation	-
About the Immunogen
Immunogen	A synthetic peptide of human VEGFC
Sequence	-
Gene ID	7424
Swiss Prot	P49767
Synonyms	VEGFC; Flt4-L; LMPH1D; VRP; vascular endothelial growth factor C
Category	Angiogenesis; Growth Factors
Background	Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular endothelial cells. VEGF and its close relatives VEGF-B, -C and -D form a subfamily within PDGF family of growth factors, which belongs to the cysteine knot class of cytokines. Five VEGF isoforms of 121, 145, 165, 189 and 206 amino acids (VEGF121–206) are generated as a result of alternative splicing from a single VEGF gene. The various VEGF forms bind to three tyrosine-kinase receptors, VEGFR-1, VEGFR-2 and VEGFR-3 which are expressed almost exclusively in endothelial cells. VEGFR-2 is the main angiogenic signal transducer for VEGF, while VEGFR-3 is specific for VEGF-C and -D and is necessary and sufficient for lymphangiogenic signaling. However, upon proteolytic processing VEGF-C and -D gain the ability to also bind and activate VEGFR-2. Guided by the binding properties of the ligands, the VEGFRs are able to form both homodimers and heterodimers. Receptor dimerization is accompanied by activation of receptor kinase activity leading to receptor autophosphorylation. Phosphorylated receptors recruit interacting proteins and induce downstream signaling. Recently, tumor therapies based on neutralizing anti-VEGF antibodies and small molecule tyrosine kinase inhibitors targeting VEGFRs have been developed. These new strategies for tumor treatment show the clinical relevance of inhibiting VEGF signal transduction pathways that are exaggerated in pathological angiogenesis.

ANTI-VEGF-C ;VEGF-C ;抗体;

公司简介

R2D上海水熊生物科技有限公司是一家致力于分子生物学领域的研发型高新技术企业，主要从事生物试剂的研发与生产，为全球科研院所、高等院校、企业用户提供创新型生物产品。产品线主要包括分子生物学通用型生物试剂、生命科学技术服务/咨询/支持、生化实验室设备耗材定置化产品。

成立日期	(9年)
注册资本	200.000000万人民币
员工人数	10-50人
年营业额	￥ 100万以内
经营模式	试剂,定制,服务
主营行业	生化试剂,抗体,蛋白组学,免疫安全