Product name: |
TNF-R2 Polyclonal Antibody |
Alternative Names: |
TNFRSF1B; TNFBR; TNFR2; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha rec |
Applications: |
WB,IHC-p,IF,ELISA |
Reactivity: |
Human,Mouse,Rat |
Gene Name: |
TNFRSF1B |
Protein Name: |
Tumor necrosis factor receptor superfamily member 1B |
Human Gene Id: |
7133 |
Human Swiss Prot No: |
P20333 |
Mouse Gene Id: |
21938 |
Mouse Swiss Prot No: |
P25119 |
Rat Gene Id: |
156767 |
Rat Swiss Prot No: |
Q80WY6 |
Immunogen: |
The antiserum was produced against synthesized peptide derived from human TNF Receptor II. AA range:376-425 |
Specificity: |
TNF-R2 Polyclonal Antibody detects endogenous levels of TNF-R2 protein. |
Formulation: |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Source: |
Rabbit |
Dilution: |
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: |
1 mg/ml |
Storage Stability: |
-20°C/1 year |
MolecularWeight(Da): |
48291 |
Observed Band(KD): |
48 |
Background: |
TNF receptor superfamily member 1B(TNFRSF1B) Homo sapiens The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008], |
Function: |
function:Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.,online information:Clinical information on Enbrel,pharmaceutical:Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors.,PTM:A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by |
Subcellular Location: |
extracellular region,nucleus,plasma membrane,integral component of plasma membrane,integral component of membrane,neuronal cell body,varicosity,membrane raft,perinuclear region of cytoplasm, |
Expression: |
Muscle,PNS,Urine, |