Anti-pan-AKT抗体

Anti-pan-AKT antibody

保存条件:-20°C
浓度:0.72 mg/ml
应用范围:ELISA, WB
适应物种:人动物植物
宿主:Rabbit
抗体英文名:Anti-pan-AKT antibody
保质期:12个月
克隆性:多克隆
数量:大量
供应商:上海机纯实业有限公司
规格25 ul/100 μul200 ul
Antipan-AKT antibody
Cat. No.JC260001
Package 25 ul/100 μul200 ul
Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Product overview
Description  Anti-pan-AKT rabbit polyclonal antibody
Applications   ELISA, WB
Immunogen   Synthetic peptide of human pan-AKT
Reativity  Human, Mouse, Rat
Content  0.72 mg/ml
Host species  Rabbit
Ig class
Immunogen-specific rabbit lgG
Purification  Antigen afinity purification

Target Background

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.