Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
产品介绍
Interleukin-21 is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells.This cytokine induces cell division/proliferation in its target cells.It has been shown that IL-21R knock-out mice express higher levels of IgE and lower levels of IgG1 than normal mice after antigen exposure. IgE levels decreased after mice were injected with IL-21. This has implications for the role of IL-21 in controlling allergic responses because of the role of IgE in hypersensitivity type 1 responses.IL-21 has been tried as therapy for alleviating allergic responses. It was shown to be successful in decreasing pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation).A study using mice with peanut allergies showed that systemic treatment of IL-21 was an effective means of mitigating the allergic response.This has strong implications for the pharmacological development of IL-21 for controlling both localized and systemic allergies.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
