RS1 (RAD51激动剂)

化学名

3-(benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide

简称

RS1

别名

RS-1, RS 1

中文名

N/A

化学式

C₂₀H₁₆Br₂N₂O₃S

分子量

524.23

CAS号

312756-74-4

纯度

98%

溶剂/溶解度

Water<1mg/ml; DMSO100mg/ml; Ethanol<1mg/ml

溶液配制

5mg加入0.95ml DMSO，或者每5.24mg加入1ml DMSO，配制成10mM溶液。SF1069-10mM用DMSO配制。

产品描述

RS-1 is a RAD51-stimulatory compound, which increases the DNA binding activity of RAD51. It is an HDR(homology-directed repair) enhancer.

信号通路

Others

靶点

RAD51

－

－

－

－

IC50

－

－

－

－

－

体外研究

RS-1 stimulates the binding of hRAD51 to ssDNA. Low-micromolar concentrations of this small molecule enhance DNA binding and result in longer protein–DNA complex lengths. In addition, RS-1 stabilizes the active form of hRAD51 filaments and this is reflected in an enhanced strand assimilation activity.

体内研究

N/A

临床实验

N/A

特征

N/A

酶活性检测实验

方法

N/A

细胞实验

细胞系

Early-passage neonatal human dermal fibroblasts

浓度

1-7.5μM

处理时间

24h

方法

Early-passage neonatal human dermal fibroblasts were maintained in Medium 106 supplemented with low serum growth supplement. Cell-survival experiments were performed using a sulforhodamine B assay. Cells are incubated for 24h in cisplatin with or without RS-1 and are subsequently incubated for an additional 6 days in normal media lacking both agents. Sulforhodamine B-stained cells are quantified with a Synergy plate reader.

动物实验

动物模型

N/A

配制

N/A

剂量

N/A

给药方式

N/A

产品编号

产品名称

包装

KL1069-10mM

RS1 (RAD51激动剂)

10mM×0.2ml

KL1069-5mg

RS1 (RAD51激动剂)

5mg

KL1069-25mg

RS1 (RAD51激动剂)

25mg

—

说明书

1份