Recombinant Human Copper, Zinc-Superoxide Dismutase (rhCu, Zn-SOD)

Alternative Name: Superoxide Dismutase1 (SOD1)
Catalog Number: NRPC01A
Packing Details: 10 KU, 100 KU, 1000 KU
Physical Appearance: Freeze-dried powder
Mol. Wt.: 17 kDa
N-terminus Sequenced: ATKAVCVLKG
Resources: Escherichia coli (E. coli)
Purity: ≥95 %
Endotoxin: < 1.0 EU/µg protein
Metals: Cadmium < 0.5 ppm; Mercury < 0.5 ppm; Lead < 6.5 ppm (1 ppm=1 µg metal/g protein)
Specific Activity: ≥10,000 IU/mg protein (Determined by NUPTEC according to modified Marklund assay at 35 oC)≥10,380 IU/mg protein (Determined by SGS according to GB/T5009.171-2003 I)
Storage Condition: -20 oC in dark place
Storage Duration: 3 years
Description:
    Superoxide dismutase (SOD) is a category of metalloenzyme, extensively existing in all living organisms (e.g. animals, plants, microorganisms, etc.). Based on its metallicity, SOD is categorized into copper, zinc-SOD (Cu, Zn-SOD), manganese-SOD (Mn-SOD) and iron-SOD (Fe-SOD). SOD has a physiological significance that can convert toxic superoxide free radicals into hydrogen peroxide. It’s the primary substance to scavenge oxygen free radicals in living organisms. It has been demonstrated that there are up to 60 diseases directly related to oxygen free radicals and SOD level has been known as an illustrated indicator for aging and death. SOD can prohibit superoxide free radicals-induced damage at cellular level and locally repair damaged cells. It plays more and more important role in anti-oxidation in living organisms. SOD is one of components in cosmetic products, approved by Ministry of Health of the People’s Republic of China, because it can delay aging, regulate immune response and blood lipid level, and prevent radiation.

Notes:
    It is recommended that the product is reconstituted with steriled water into a final concentration of 1 mg/ml (10 KU/ml). Store the reconstituted product in aliquots at -20 °C in dark place. Avoid multiple freeze-thaw cycles and exposure to frequent temperature changes.
The use of strong acids and alkalis, strong oxidants, and high concentrations of organic solvents should be avoided to protect the product from denaturation.