Recombinant Rat BRAK/CXCL14

Name

Recombinant Rat BRAK/CXCL14 (Recombinant Rat Breast and Kidney-expressed Chemokine/CXCL14; rRtBRAK/CXCL14)；重组大鼠乳腺癌和肾脏表达趋化因子/CXCL14

Synonyms

Bolekine; BRAK; CXC-X3; BMAC; BRAKKEC; chemokine (C-X-C motif) ligand 14; Chemokine BRAK; member 14 (BRAK); MIP-2 gamma; MIP2G; MIP-2G; NJACKec; SCYB14MGC10687; Small-inducible cytokine B14

Purity

>95% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 1.0-10ng/ml.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in 30% Acetonitrile and 0.1% TFA.

Endotoxin

Less than 0.1EU/μg of rRtBRAK/CXCL14 as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Chemokines

Background

Chemokine (C-X-C motif) ligand 14 (CXCL14), also named BRAK, is a small cytokine belonging to the CXC chemokine family. It is constitutively expressed at the mRNA level in certain normal tissues and it possesses chemoattractive activity for activated macrophages, immature dendritic cells and natural killer cells. According to the relevant literature, CXCL14 is associated with tumor development. Moreover, recent evidence revealed that CXCL14 participates in glucose metabolism, feeding behaviour-associated neuronal circuits, and anti-microbial defense. Although CXCL14 receptors have not yet been identified, the intracellular activity of CXCL14 in breast cancer cells suggests that the CXCL14 receptor(s) and signal transduction pathway(s) may be different from those of conventional CXC-type chemokines. Recombinant rat CXCL14 contains 77 amino acid residues and it shares 99%a.a. sequence identity with human and murine CXCL14.

Amino Acid Sequence

SKCKCSRKGP KIRYSDVKKL EMKPKYPHCE EKMVIITTKS MSRYRGQEHC LHPKLQSTKR FIKWYNAWNE KRRVYEE

产品编号

产品名称

包装

KL6893-5μg

Recombinant Rat BRAK/CXCL14

5μg

KL-6893-20μg

Recombinant Rat BRAK/CXCL14

20μg

KL-6893-100μg

Recombinant Rat BRAK/CXCL14

100μg

KL-6893-1mg

Recombinant Rat BRAK/CXCL14

1mg

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说明书

1份