Recombinant Rhesus Macaque IFN-γ

Name

Recombinant Rhesus Macaque IFN-γ (Recombinant Rhesus Macaque Interferon-gamma; rRhIFN-γ)；重组恒河猴干扰素γ

Synonyms

Interferon gamma; IFN-gamma; IFNG

Purity

>97% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by an anti-viral assay using human HeLa cells infected with encephalomyocarditis (EMC) virus is less than 20.0ng/ml, corresponding to a specific activity of >5.0×10⁴IU/mg.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4.

Endotoxin

Less than 0.1EU/μg of rRhIFN-γ as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Cytokine

Background

Interferon-gamma (IFN-γ), also known as Type II interferon or immune interferon, is a cytokine produced primarily by Tlymphocytes and natural killer cells. The protein shares no significant homology with IFN-β or the various IFN-α family proteins. Mature IFN-γ exists as noncovalently-linked homodimers. IFN-γ was originally characterized based on its antiviral activities. The protein also exerts antiproliferative, immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms. IFN-γ induces the production of cytokines, upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. IFN-γ also augments TH1 cell expansion and may be required for TH1 cell differentiation.

Amino Acid Sequence

QDPYVKEAEN LKKYFNAGDP DVADNGTLFL DILRNWKEES DRKIMQSQIV SFYFKLFKNF KDDQRIQKSV ETIKEDINVK FFNSNKKKRD DFEKLTNYSV TDSNVQRKAV HELIQVMAEL SPAAKIGKRK RSQMFRGRRA SQ

产品编号

产品名称

包装

KL-5887-10μg

Recombinant Rhesus Macaque IFN-γ

10μg

KL-5887-50μg

Recombinant Rhesus Macaque IFN-γ

50μg

KL-5887-100μg

Recombinant Rhesus Macaque IFN-γ

100μg

KL-5887-1mg

Recombinant Rhesus Macaque IFN-γ

1mg

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说明书

1份