Recombinant Human IGF-BP7

Name

Recombinant Human IGF-BP7 (Recombinant Human Insulin-like Growth Factor-Binding Protein 7; rHuIGF-BP7)；重组人胰岛素样生长因子结合蛋白7

Synonyms

IGFBP7; IGFBP-7; Mac25; PSF; angiomodulin; FSTL2; IBP-7; IGFBP-7PGI2-stimulating factor; IGFBP-7v; IGFBPRP1; IGFBP-rP1; insulin-like growth factor binding protein 7; insulin-like growth factor-binding protein 7; MAC25 protein; MAC25IGF-binding protein 7; Prostacyclin-stimulating factor; PSFAGM; TAF; Tumor-derived adhesion factor

Purity

>95% by SDS-PAGE and HPLC analyses.

Biological Activity

Testing in Progress.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in 20mM Tris-HCl, pH8.6, 150mM NaCl.

Endotoxin

Less than 0.1EU/μg of rHuIGF-BP7 as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Cytokine

Background

IGF-BP7, also named IBP-7, Mac25 and IGFBPrP1, is belonging to the superfamily of insulin-like growth factor (IGF) binding proteins and is encoded by the igfbp7 gene in human. It is expressed in a wide range of normal human tissues and it generally shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. IGF-BP7 includes conserved cysteine residues. IGF-BP7 modulates the biological activities of IGF proteins. It also suppresses growth and colony formation of prostate and breast cancer cell lines. Above all, IGF-BP7 is a very important factor in skeletal myogenesis. Human IGF-BP7 cDNA encodes 282 amino acid (a.a.) residue precursor protein with a putative 26a.a. signal peptide. Human and murine IGF-BP7 share 94%a.a. sequence identity.

Amino Acid Sequence

SSSDTCGPCE PASCPPLPPL GCLLGETRDA CGCCPMCARG EGEPCGGGGA GRGYCAPGME CVKSRKRRKG KAGAAAGGPG VSGVCVCKSR YPVCGSDGTT YPSGCQLRAA SQRAESRGEK AITQVSKGTC EQGPSIVTPP KDIWNVTGAQ VYLSCEVIGI PTPVLIWNKV KRGHYGVQRT ELLPGDRDNL AIQTRGGPEK HEVTGWVLVS PLSKEDAGEY ECHASNSQGQ ASASAKITVV DALHEIPVKK GEGAEL

产品编号

产品名称

包装

KL-5525-5μg

Recombinant Human IGF-BP7

5μg

KL-5525-25μg

Recombinant Human IGF-BP7

25μg

KL-5525-100μg

Recombinant Human IGF-BP7

100μg

KL-5525-1mg

Recombinant Human IGF-BP7

1mg

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说明书

1份