Recombinant Human BMP-7 (Recombinant Human Bone Morphogenetic Protein 7; rHuBMP-7);重组人骨形态发生蛋白7
Synonyms
OP-1; BMP-7; bone morphogenetic protein 7; Eptotermin alfa; OP-1OP1; Osteogenic protein 1
Purity
>95% by SDS-PAGE and HPLC analyses.
Biological Activity
Data is not available.
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized from a 0.2μM filtered concentrated solution in 30% acetonitrile, 0.1% TFA.
Endotoxin
Less than 1EU/μg of rHuBMP-7 as determined by LAL method.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10mM HAc to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.
Category
Cytokine
Background
Bone Morphogenetic Protein 7 is one of the BMPs, some of which belong to the TGF-β superfamily (BMP2-7). There are more than thirteen BMPs have been discovered nowadays and they are involved in inducing cartilage and bone formation. BMP-7 is mainly expressed in kidney and bladder. It is also present in developing eyes, brain and ear during embryogenesis. BMP-7 also named osteogenic protein-1 (OP-1) is a potent osteoinductive cytokine and plays role in osteoblast differentiation, SMAD1 production and renal development and repair. Human BMP-7 is synthesized with a signal sequence (29a.a.), a propeptide (263a.a.), and a growth factor domain (139a.a.). The growth factor domain of human BMP-7 shares 98%a.a. sequence identity with mouse and rat BMP-7.