Recombinant Human TWEAK Receptor/TNFRSF12A

Name

Recombinant Human TWEAK Receptor/TNFRSF12A (Recombinant Human TNF-related Weak Inducer of Apoptosis Receptor; rHuTWEAK Receptor)；重组人肿瘤坏死因子相关的弱受体细胞凋亡的诱导/TNFRSF12A

Synonyms

CD266; Fn14; TNFRSF12; TNFRSF12A; CD266; CD266 antigen; FGF-inducible 14; Fibroblast growth factor-inducible immediate-early response protein 14; FN14tumor necrosis factor receptor superfamily member 12A; tumor necrosis factor receptor superfamily, member 12A; TWEAKR; TweakR; tweak-receptor; Tweak-receptor; type I transmembrane protein Fn14

Purity

>95% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by inhibiting TWEAKdependent proliferation of human umbilical vein endothelial cells (HUVEC) is less than 30ng/ml, corresponding to a specific activity of >3.3×10⁴IU/mg, in the presence of 15ng/ml of rHuTWEAK.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4.

Endotoxin

Less than 1EU/μg of rHuTWEAK Receptor as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Cytokine

Background

Human TNF-related weak inducer of apoptosis receptor (TWEAKR) also known as Tumor necrosis factor receptor superfamily member 12A precursor (gene name TNFRSF12A) or fibroblast growth factor-inducable 14kDa protein, is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAK receptor can be activated by either the membrane anchored or the soluble TWEAK. In addition, It plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. Human and mouse TWEAK R share 82%a.a. sequence identity.

Amino Acid Sequence

EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP

产品编号

产品名称

包装

KL-5385-5μg

Recombinant Human TWEAK Receptor/TNFRSF12A

5μg

KL-5385-25μg

Recombinant Human TWEAK Receptor/TNFRSF12A

25μg

KL-5385-100μg

Recombinant Human TWEAK Receptor/TNFRSF12A

100μg

KL--5385-1mg

Recombinant Human TWEAK Receptor/TNFRSF12A

1mg

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说明书

1份