常乐康

[Drug name]
Generic name: Combined Clostridium Butyricum and Bifidobacterium Powders, Live
Brand name: Clobico

[Ingredients]   
Active ingredient: Clostridium butyricum, Bifidobacterium infantis
Inactive ingredient: Corn starch, Anhydrous glucose

[Character]
This product shall be white or grayish white powder.

[Indications]
Indicated for intestinal flora imbalance and related acute and chronic diarrhea and dyspepsia.

[Specification]
500mg / sachet (within the shelf life, each sachet contains clostridium butyricum with the viable count of not less than 1.0Î107 CFU/g and bifidobacterium infantis with the viable count of not less than 1.0Î106 CFU/g)

[Usage and dosage]
Oral administration, 3 sachets a time, twice a day. For acute diarrhea, continuously use for 3~7 days; for chronic diarrhea, continuously use for 14~21 days.
 
[Side effects]
The Phase I ~ III of Clinical trial have showed that a few patients slightly developed skin rash and stomach upset.

[Contraindications]
Not to be taken by those who are allergic to probiotics.

[Announcements]
Not to be taken with hot water.

[Medication for pregnant women and lactation female]
It can be taken by the pregnant women and lactation female.
 

[Medication for children]
Oral administration, 1 sachet a time, twice a day. It can be taken with cold boiled water, juice and milk.

[Drug interaction]
Not to be taken with antibiotics at the same time.

[Drug overdose] 
This product is probiotics. No overdose is reported.


[Pharmacology& Toxicology]
The pharmacodynamics test in mice showed that this product can stop diarrhea caused by ampicillin. Clostridium butyricum can inhibit the growth of intestinal pathogenic bacteria such as el tor vibrio cholerae 01 group, vibrio cholerae 0139, escherichia coli 0157, etc. This product can also inhibit the growth of shigella dysentery and salmonella porcine cholera.

[Pharmacokinetics]
Clostridium butyricum can be colonized temporarily in the intestinal tract and kept for about ten days before being eliminated from the body. Bifidobacterium infantis is a resident beneficial bacterium, which can be colonized and grown in the intestinal tract after oral administration.

[Storage]  
Store at 2~8 ºC and protect from light.

[Package]
Packing material: medicinal composite membrane
Packing specification: 500mg / sachet, 10 sachets / box

[Shelf life]
24 months      



[Manufacturing enterprise]
Manufacturer: Shandong Kexing Bioproducts Co., Ltd.
Manufacturing site: No. 2666 Chuangye Road, Mingshui Development Zone, Zhangqiu, Shandong, China
 
URL: www.gzpharm.com.cn/