2019-nCoV S蛋白

描述：

Recombinant 2019-nCoV S Protein RBD is produced by our Mammalian expression system and the target gene encoding Asn331-Val524 is expressed with a mFc tag at the C-terminus.

Accession:  QHD43416.1

别名：S protein RBD; 2019-nCoV S protein RBD

来源：Human Cells

分子量：Mol Mass: 47.9kDa AP Mol Mass: 50-60kDa, reducing conditions

形态：Supplied as a 0.2 μM filtered solution of PBS, pH 7.4

纯化方法：Affinity purification chromatography.

纯度：Greater than 95% as determined by reducing SDS-PAGE.

活性：The ED50 of 2019-nCoV S Protein RBD-mFc is 62 ng/ml.

储存/保存方法：Reconstituted protein solution should be stored at ≤ -20°C.

背景说明：

Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

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