Bax Antibody

ProSci Incorporated 於1998年成立于世界生物城之一的美国加州圣地亚哥市，是世界最早和的细胞凋亡抗体生产厂家和供应商，公司现拥有17000多种单、多克隆抗体，产品涵盖了细胞凋亡、信号转导、免疫、肿瘤、细胞生物、神经生物、传染病等领域。ProSci公司的抗体大都经免疫亲和层析纯化，经过了严格的验证测试和质量控制，具有高纯度、高亲和力、特异性强等特点，可用于免疫印迹（Western blot），免疫组织化学（IHC），免疫细胞化学（ICC），酶联免疫吸附实验（ELISA）和细胞流式分析（FACS）等方面。ProSci的抗体产品已应用在1281篇SCI论文中，其中2011年的有228篇，ProSci的经销商和客户都对ProSci的产品质量和服务十分满意，ProSci公司在2003、2007、2010年度都被《Nature》评为免疫学试剂推荐品牌，抗体研发、生产和服务优秀供应商。
Bax Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bax, a pro-apoptotic Bcl-2 family member, is a cytosolic protein that changes conformation and translocates to the mitochondria following apoptotic stimuli. It is thought to share significant functional homology with Bak, another pro-apoptotic Bcl-2 family member, as disruption of bax or bak has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking both show decreased apoptotic capability.