BOC Antibody

 

 BOC Antibody
 

Cat#：PL0402543
 

Isotype:Rabbit Polyclonal IgG
 

Immunogen：peptide corresponding to a sequence at the C-terminus of mouse BOC. 
 

Purification: Immunogen affinity purified

Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)

Background：

BOC(Brother Of CDO) also known as BROTHER OF CDON and BOC are cell surface receptors of the immunoglobulin(Ig)/fibronectin type III repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail. The domain structure of BOC is similar to that of CDON, and the 2 proteins share 38 to 80% amino acid identity in the individual extracellular domains. The International Radiation Hybrid Mapping Consortium mapped the BOC gene to chromosome 3. In contrast with CDON, the intracellular region of BOC was not essential for its ability to positively regulate differentiation.BOC is dependent on CDON for activity and that CDON-BOC complexes function to regulate myogenic differentiation. Wegorzewska et al.(2003) proposed that CDO and BOC play a role in the inverse relationship between differentiation and transformation of cells in the skeletal muscle lineage.

Specificity Reaction：Mo，Rat

 

Application Notes:WB: 1:100-500

 

Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.

 

 

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